ArticleMolecular and cellular biology1998
Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.Nature communications · 2025Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.Nature communications · 2021Article
- Interplay between HMGA and TP53 in cell cycle control along tumor progression.Cellular and molecular life sciences : CMLS · 2021Review
- E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.Animals : an open access journal from MDPI · 2020Article
- Article
- E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.The Journal of experimental medicine · 2011Article
- Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells.International journal of hematology · 2008Article
- The LIM-only protein FHL2 is a negative regulator of E4F1.Oncogene · 2006Article
- E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.Genes & development · 2006Article
- E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.The American journal of pathology · 2004Article
- ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.Journal of virology · 2004Article
- The E4F protein is required for mitotic progression during embryonic cell cycles.Molecular and cellular biology · 2004Article
- Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.Molecular and cellular biology · 2003Article
- Article
- Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.Molecular and cellular biology · 2001Article
- pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- p53 is involved in the p120E4F-mediated growth arrest.Oncogene · 2000Article
- Suppression of E1A-mediated transformation by the p50E4F transcription factor.Molecular and cellular biology · 1999Article
- Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adenovirus E1A proteins influence cell growth and phenotype through physical interactions with cellular proteins that regulate basic processes such as cell cycle progression, DNA synthesis, and differentiation. p120E4F is a low-abundance cellular transcription factor that represses the adenovirus E4 promoter and is regulated by E1A, through a phosphorylation-induced reduction of its DNA binding activity, to permit activation of the E4 promoter during early infection. To determine the normal biological role of p120E4F, we assessed its ability to influence fibroblast cell growth and transformation. p120E4F suppressed NIH 3T3 fibroblast colony formation but had little effect when coexpressed with E1A and/or activated ras. Cells that overexpressed p120E4F were inhibited in their ability to enter S phase, had elevated levels of the cdk inhibitor p21WAF1, and reduced cyclin D-cdk4/6 kinase activity. The increase of p21WAF1 levels occurred through a p53-independent posttranscriptional mechanism that included a three- to fourfold increase in the half-life of p21WAF1 protein. Coexpression of activated ras with p120E4F stimulated cyclin D1 expression, elevated cyclin D-cdk4/6 kinase activity, and accelerated cell growth. These data suggest an important role for p120E4F in normal cell division and demonstrate that p21WAF1 can be regulated by protein turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.