ArticleMolecular and cellular biology1998
Opposite transcriptional effects of cyclic AMP-responsive elements in confluent or p27KIP-overexpressing cells versus serum-starved or growing cells.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly.PLoS pathogens · 2015Article
- Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Article
- Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species.Journal of virology · 2010Article
- Augmented transgene expression in transformed cells using a parvoviral hybrid vector.Cancer gene therapy · 2008Article
- Targeting of autonomous parvoviruses to colon cancer by insertion of Tcf sites in the P4 promoter.Cancer gene therapy · 2006Article
- Expression profiling of human hepatoma cells reveals global repression of genes involved in cell proliferation, growth, and apoptosis upon infection with parvovirus H-1.Journal of virology · 2005Article
- The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression.Molecular and cellular biology · 2003Article
- Replicating parvoviruses that target colon cancer cells.Journal of virology · 2003Article
- NS1- and minute virus of mice-induced cell cycle arrest: involvement of p53 and p21(cip1).Journal of virology · 2001Article
- CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.Journal of virology · 2001Article
- Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.Gene therapy · 2000Article
- Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites.Molecular and cellular biology · 1999Article
- Activation of promoter P4 of the autonomous parvovirus minute virus of mice at early S phase is required for productive infection.Journal of virology · 1999Article
- p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry.Oncogene · 1999Article
- The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Replicative functions of minute virus of mice NS1 protein are regulated in vitro by phosphorylation through protein kinase C.Journal of virology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The minute virus of mice, an autonomous parvovirus, requires entry of host cells into the S phase of the cell cycle for its DNA to be amplified and its genes expressed. This work focuses on the P4 promoter of this parvovirus, which directs expression of the transcription unit encoding the parvoviral nonstructural polypeptides. These notably include protein NS1, necessary for the S-phase-dependent burst of parvoviral DNA amplification and gene expression. The activity of the P4 promoter is shown to be regulated in a cell cycle-dependent manner. At the G1/S-phase transition, the promoter is activated via a cis-acting DNA element which interacts with phase-specific complexes containing the cellular transcription factor E2F. It is inhibited, on the other hand, in cells arrested in G1 due to contact inhibition. This inhibitory effect is not observed in serum-starved cells. It is mediated in cis by cyclic AMP response elements (CREs). Unlike serum-starved cells, confluent cells accumulate the cyclin-dependent kinase inhibitor p27, suggesting that the switch from CRE-mediated activation to CRE-mediated repression involves the p27 protein. Accordingly, plasmid-driven overexpression of p27 causes down-modulation of promoter P4 in growing cells, depending on the presence of at least two functional CREs. No such effect is observed with two other cyclin-dependent kinase inhibitors, p16 and p21. Given the importance of P4-driven synthesis of protein NS1 in parvoviral DNA amplification and gene expression, the stringent S-phase dependency of promoter P4 is likely a major determinant of the absolute requirement of the minute virus of mice for host cell proliferation.
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