ArticleMolecular and cellular biology1998
Heat shock factor increases the reinitiation rate from potentiated chromatin templates.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- The Mediator complex: co-transcriptional regulation and beyond.RNA biology · 2026Review
- Adaptive Variation Amid High Gene Flow Across a Broad Latitudinal Gradient in the Reef-Building Honeycomb Worm, Sabellaria alveolata.Molecular ecology · 2026Article
- Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands.Nature communications · 2021Article
- Chromatin remodeling effects on enhancer activity.Cellular and molecular life sciences : CMLS · 2016Review
- The Mediator complex: a central integrator of transcription.Nature reviews. Molecular cell biology · 2015Review
- Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation.Transcription · 2014Review
- Investigating transcription reinitiation through in vitro approaches.Transcription · 2014Review
- HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.Journal of biomedicine & biotechnology · 2011Article
- Drosophila heat shock system as a general model to investigate transcriptional regulation.Cold Spring Harbor symposia on quantitative biology · 2010Review
- The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.Genes & development · 2009Article
- Regulation of TATA-binding protein dynamics in living yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Molecular and cellular biology · 2005Article
- Self-organization vs Watchmaker: stochastic gene expression and cell differentiation.Development genes and evolution · 2005Article
- Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation.Molecular and cellular biology · 2003Article
- Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates.Molecular and cellular biology · 2003Article
- Redundant cooperative interactions for assembly of a human U6 transcription initiation complex.Molecular and cellular biology · 2002Article
- Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB.Molecular and cellular biology · 2002Article
- Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation.Molecular and cellular biology · 2002Article
- Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells.Nucleic acids research · 2001Article
- Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines.Cell stress & chaperones · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription by RNA polymerase II is highly regulated at the level of initiation and elongation. Well-documented transcription activation mechanisms, such as the recruitment of TFIID and TFIIB, control the early phases of preinitiation complex formation. The heat shock genes provide an example for transcriptional regulation at a later step: in nuclei TFIID can be detected at the TATA box prior to heat induction. Using cell-free systems for chromatin reconstitution and transcription, we have analyzed the mechanisms by which heat shock factor (HSF) increases transcription of heat shock genes in chromatin. HSF affected transcription of naked DNA templates in multiple ways: (i) by speeding up the rate of preinitiation complex formation, (ii) by increasing the number of productive templates, and (iii) by increasing the reinitiation rate. Under the more physiological conditions of potentiated chromatin templates, HSF affected only the reinitiation rate. Activator-dependent reinitiation of transcription, obviating the slow assembly of the TFIID-TFIIA complex on a promoter, may be especially crucial for genes requiring a fast response to inducers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.