Trial reportMedizinische Klinik (Munich, Germany : 1983)1997
[Selenium administration in patients with sepsis syndrome. A prospective randomized study].
Trial report in Medizinische Klinik (Munich, Germany : 1983), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials.European journal of medical research · 2023Pooled it
- The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials.Medicine · 2019Pooled it
- A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.Medicine · 2019Pooled it
- High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis.Critical care (London, England) · 2016Pooled it
- Selenium supplementation for critically ill adults.The Cochrane database of systematic reviews · 2015Pooled it
- Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis.Critical care (London, England) · 2012Pooled it
- Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.The Cochrane database of systematic reviews · 2012Pooled it
- Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients.The Cochrane database of systematic reviews · 2006Pooled it
- Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient.Intensive care medicine · 2005Pooled it
- High-dose selenium substitution in sepsis: a prospective randomized clinical trial.Intensive care medicine · 2011Trial
- Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study.Critical care (London, England) · 2007Trial
- Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?Intensive care medicine experimental · 2019Review
- Thiol-Redox Regulation in Lung Development and Vascular Remodeling.Antioxidants & redox signaling · 2019Review
- Selenium: implications for outcomes in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Review
- Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats.EXCLI journal · 2017Article
- Adjuvant selenium supplementation in the form of sodium selenite in postoperative critically ill patients with severe sepsis.Critical care (London, England) · 2014Article
- Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?Critical care (London, England) · 2007Article
- Seleno-enzymes and seleno-compounds: the two faces of selenium.Critical care (London, England) · 2006Article
- [Significance of selenium in regulation of inflammatory response by transcription factors in polytrauma patients. A clinical study].Medizinische Klinik (Munich, Germany : 1983) · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PATIENTS AND
methodIn this study the effect of antioxidative therapy with sodium selenite was investigated in patients with systemic inflammatory response syndrome (S. I. R. S.) and multiple organ failure. 40 patients were included in this prospective randomized study. The patients were observed over a period of 28 days. The letality rate within 28 days was excepted as main criteria. The Apache-II and the MOF-Score of Goris were used as clinical parameters. 20 patients were treated with sodium selenite over a period of 28 days.
resultThis antioxidative therapy reduced the letality rate from 40 to 15%.
Indexed as
Identifiers
9417494What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.