ArticleImmunology1997
Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
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- LY6E impairs coronavirus fusion and confers immune control of viral disease.Nature microbiology · 2020Article
- Role of cytotoxic T lymphocytes and interferon-γ in coronavirus infection: Lessons from murine coronavirus infections in mice.The Journal of veterinary medical science · 2020Review
- Human genetic basis of fulminant viral hepatitis.Human genetics · 2020Review
- Nanocarriers for spleen targeting: anatomo-physiological considerations, formulation strategies and therapeutic potential.Drug delivery and translational research · 2016Review
- Toll-like receptor-2 exacerbates murine acute viral hepatitis.Immunology · 2016Article
- HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration.The Journal of biological chemistry · 2013Article
- TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice.BMC gastroenterology · 2011Article
- Mouse adenovirus type 1 infection of macrophages.Virology · 2009Article
- Article
- Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep.Journal of virology · 2006Article
- Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infection.Immunology · 2002Article
- Murine hepatitis virus--a model for virus-induced CNS demyelination.Journal of neurovirology · 2002Review
- Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to their scavenging and phagocytic functions, spleen macrophages are regarded to be important in the induction and maintenance of both innate and acquired immune defence mechanisms. In this study, we investigated the role of spleen macrophages in immunity against mouse hepatitis virus strain A59 (MHV-A59). Previous studies showed that spleen and liver macrophages are the first target cells for infection by MHV-A59 in vivo, suggesting that they could be involved in the induction of immune responses against MHV-A59. We used a macrophage depletion technique to deplete macrophages in vivo and studied the induction of virus-specific antibody and cytotoxic T-cell (CTL) responses and non-immune resistance against MHV-A59 in normal and macrophage-depleted mice. Virus titres in spleen and liver increased rapidly in macrophage-depleted mice, resulting in death of mice within 4 days after infection. Elimination of macrophages before immunization with MHV-A59 resulted in increased virus-specific humoral and T-cell proliferative responses. However, virus-specific CTL responses were not altered in macrophage-depleted mice. Our results show that spleen macrophages are of major importance as scavenger cells during MHV-A59 infection and are involved in clearance of virus from the host. In addition, macrophages may be involved in the regulation of acquired immune responses. In the absence of macrophages, increased virus-specific T-cell and antibody responses are detectable, suggesting that macrophages suppress MHV-A59-specific T- and B-cell responses and that other cells serve as antigen-presenting cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.