ArticleBiophysical journal1997
Electrotonic measurements by electric field-induced polarization in neurons: theory and experimental estimation.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 29 citations in OpenAlex.
- Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields.Cognitive neurodynamics · 2024Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Cortical neuron activation induced by electromagnetic stimulation: a quantitative analysis via modelling and simulation.Journal of computational neuroscience · 2016Article
- Exploring how extracellular electric field modulates neuron activity through dynamical analysis of a two-compartment neuron model.Journal of computational neuroscience · 2014Article
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- The effect of spatially inhomogeneous extracellular electric fields on neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Field effects in the CNS play functional roles.Frontiers in neural circuits · 2010Article
- Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro.Brain stimulation · 2009Article
- Local facilitation of plateau potentials in dendrites of turtle motoneurones by synaptic activation of metabotropic receptors.The Journal of physiology · 1999Article
- An estimator for the electrotonic size of neurons independent of charge equalization time constants.Journal of computational neuroscienceArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a theory for estimation of the dendritic electrotonic length constant and the membrane time constant from the transmembrane potential (TMP) induced by an applied electric field. The theory is adapted to morphologically defined neurons with homogeneous passive electric properties. Frequency characteristics and transients at the onset and offset of the DC field are considered. Two relations are useful for estimating the electrotonic parameters: 1) steady-state polarization versus the dendritic electrotonic length constant; 2) membrane time constant versus length constant. These relations are monotonic and may provide a unique estimate of the electrotonic parameters for 3D-reconstructed neurons. Equivalent tip-to-tip electrotonic length of the dendritic tree was estimated by measuring the equalization time of the field-induced TMP. For 11 turtle spinal motoneurons, the electrotonic length from tip to tip of the dendrites was in the range of 1-2.5 lambda, whereas classical estimation using injection of current pulses gave an average dendrite length of 0.9-1.1 lambda. For seven ventral horn interneurons, the estimates were 0.7-2.6 lambda and 0.6-0.9 lambda, respectively. The measurements of the field-induced polarization promise to be a useful addition to the conventional methods using microelectrode stimulation.
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