ArticleBiophysical journal1997
Calculation of diffusion-limited kinetics for the reactions in collision coupling and receptor cross-linking.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Measuring the Adsorption Cross Section of YOYO-1 to Immobilized DNA Molecules.The journal of physical chemistry. B · 2024Article
- Hypericin, a potential new BH3 mimetic.Frontiers in pharmacology · 2022Article
- A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors.Frontiers in pharmacology · 2020Article
- Article
- Effect of Hydrodynamic Interactions on Reaction Rates in Membranes.Biophysical journal · 2017Article
- Dynamic disorder in simple enzymatic reactions induces stochastic amplification of substrate.Journal of the Royal Society, Interface · 2017Article
- Nanoscale diffusion in the synaptic cleft and beyond measured with time-resolved fluorescence anisotropy imaging.Scientific reports · 2017Article
- Article
- The membrane environment can promote or suppress bistability in cell signaling networks.The journal of physical chemistry. B · 2012Article
- Impact of receptor clustering on ligand binding.BMC systems biology · 2011Article
- Quantitative understanding of cell signaling: the importance of membrane organization.Current opinion in biotechnology · 2010Review
- Article
- Analysis of reaction-diffusion systems with anomalous subdiffusion.Biophysical journal · 2009Article
- Adhesive dynamics simulation of G-protein-mediated chemokine-activated neutrophil adhesion.Biophysical journal · 2009Article
- Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results?Journal of theoretical biology · 2008Article
- Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk.Biophysical journal · 2008Article
- Diffusion-limited reactions in G-protein activation: unexpected consequences of antagonist and agonist competition.Journal of theoretical biology · 2008Article
- Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides.Analytical biochemistry · 2007Article
- Dimerization of VEGF receptors and implications for signal transduction: a computational study.Biophysical chemistry · 2007Article
- The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy.Analytical biochemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both enzyme (e.g., G-protein) activation via a collision coupling model and the formation of cross-linked receptors by a multivalent ligand involve reactions between two molecules diffusing in the plasma membrane. The diffusion of these molecules is thought to play a critical role in these two early signal transduction events. In reduced dimensions, however, diffusion is not an effective mixing mechanism; consequently, zones in which the concentration of particular molecules (e.g., enzymes, receptors) becomes depleted or enriched may form. To examine the formation of these depletion/ accumulation zones and their effect on reaction rates and ultimately the cellular response, Monte Carlo techniques are used to simulate the reaction and diffusion of molecules in the plasma membrane. The effective reaction rate at steady state is determined in terms of the physical properties of the tissue and ligand for both enzyme activation via collision coupling and the generation of cross-linked receptors. The diffusion-limited reaction rate constant is shown to scale with the mean square displacement of a receptor-ligand complex. The rate constants determined in the simulation are compared with other theoretical predictions as well as experimental data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.