ArticleBritish journal of cancer1997
Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- The Expression of Testin, Ki-67 and p16 in Cervical Cancer Diagnostics.Current issues in molecular biology · 2023Article
- Performance of the UroVysionCancer medicine · 2018Article
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- Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.The Prostate · 2011Article
- Common fragile site tumor suppressor genes and corresponding mouse models of cancer.Journal of biomedicine & biotechnology · 2011Review
- Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene.Molecular cancer · 2010Article
- Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells.The American journal of pathology · 2008Article
- Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity.World journal of gastroenterology · 2006Article
- Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer.World journal of gastroenterology · 2006Review
- Knockout mice reveal a tumor suppressor function for Testin.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Article
- Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis.World journal of gastroenterology · 2004Article
- Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.World journal of gastroenterology · 2003Article
- Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas.British journal of cancer · 2003Article
- Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene.The American journal of pathology · 2001Article
- Chromosomal alterations in paired gastric adenomas and carcinomas.The American journal of pathology · 2001Article
- Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site.Oncogene · 2000Article
- Construction of a high-resolution physical map of the approximate 1-Mb region of human chromosome 7q31.1-q31.2 harboring a putative tumor suppressor gene.Neoplasia (New York, N.Y.) · 1999Article
- Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.The EMBO journal · 1998Article
- Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies.Neoplasia (New York, N.Y.)Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Loss of heterozygosity (LOH) at several chromosomal loci is a common event in human malignancies. Frequent LOH on the long arm of chromosome 7 has been reported in various human malignancies, and investigators have identified the most common site of LOH as 7q31.1. We have identified ten chromosomal loci, including chromosome 7q, that have been shown by previous allelotype study to be sites of frequent LOH in differentiated adenocarcinoma of the stomach. In the present study, we performed a polymerase chain reaction (PCR) microsatellite analysis to define the common deleted region on 7q, using 14 polymorphic microsatellite markers in matched tumour and non-tumour DNAs from 53 patients with primary gastric carcinoma of the differentiated type. LOH at any locus on 7q occurred in 34% (18 out of 53) of the tumours. Although many tumours exhibited total or large interstitial deletions, we determined the smallest common deleted region to be at D7S480 (7q31.1). This is identical to the region identified for other human malignancies. These observations indicate that a putative tumour suppressor gene at 7q31.1 may be involved in the pathogenesis of differentiated adenocarcinoma of the stomach.
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