ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Laminin directs growth cone navigation via two temporally and functionally distinct calcium signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Cell adhesion and intracellular calcium signaling in neurons.Cell communication and signaling : CCS · 2013Pooled it
- Axon Guidance and Collective Cell Migration by Substrate-Derived Attractants.Frontiers in molecular neuroscience · 2019Article
- Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells.Frontiers in cellular neuroscience · 2017Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices.Lab on a chip · 2010Article
- Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish.Developmental biology · 2009Article
- Article
- Review
- Intracellular localization of the HCS2 gene products in identified snail neurons in vivo and in vitro.Cellular and molecular neurobiology · 2006Article
- Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3.The Journal of cell biology · 2005Article
- Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Guiding neuronal growth cones using Ca2+ signals.Trends in cell biology · 2004Review
- Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Modeling the role of myosin 1c in neuronal growth cone turning.Biophysical journal · 2003Article
- Direct cAMP signaling through G-protein-coupled receptors mediates growth cone attraction induced by pituitary adenylate cyclase-activating polypeptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Intracellular signaling by the neural cell adhesion molecule.Neurochemical research · 2003Review
- Gradients of substrate-bound laminin orient axonal specification of neurons.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone.The Journal of cell biology · 2002Article
- Regulation of structural plasticity by different channel types in rod and cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During development, growth cones navigate to their targets via numerous interactions with molecular guidance cues, yet the mechanisms of how growth cones translate guidance information into navigational decisions are poorly understood. We have examined the role of intracellular Ca2+ in laminin (LN)-mediated growth cone navigation in vitro, using chick dorsal root ganglion neurons. Subsequent to contacting LN-coated beads with filopodia, growth cones displayed a series of stereotypic changes in behavior, including turning toward LN-coated beads and a phase of increased rates of outgrowth after a pause at LN-coated beads. A pharmacological approach indicated that LN-mediated growth cone turning required an influx of extracellular Ca2+, likely in filopodia with LN contact, and activation of calmodulin (CaM). Surprisingly, fluorescent Ca2+ imaging revealed no LN-induced rise in intracellular Ca2+ in filopodia attached to their parent growth cone. However, isolation of filopodia by laser-assisted transection unmasked a rapid, LN-specific rise in intracellular Ca2+ (+73 +/- 11 nM). Additionally, a second, sustained rise in intracellular Ca2+ (+62 +/- 8 nM) occurred in growth cones, with a distinct delay 28 +/- 3 min after growth cone filopodia contacted LN-coated beads. This delayed, sustained Ca2+ signal paralleled the phase of increased rates of outgrowth, and both events were sensitive to the inhibition of Ca2+/CaM-dependent protein kinase II (CaM-kinase II) with 2 microM KN-62. We propose that LN-mediated growth cone guidance can be attributed, in part, to two temporally and functionally distinct Ca2+ signals linked by a signaling cascade composed of CaM and CaM-kinase II.
Indexed as
Identifiers
9412499PMC6793400W2104870434What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.