ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.bioRxiv : the preprint server for biology · 2023Article
- Allosteric proteins as logarithmic sensors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Phosphorylation via PKC Regulates the Function of the Drosophila Odorant Co-Receptor.Frontiers in cellular neuroscience · 2011Article
- The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.Current pharmaceutical design · 2006Review
- A cyclic GMP-dependent calcium-activated chloride current in smooth-muscle cells from rat mesenteric resistance arteries.The Journal of general physiology · 2004Article
- Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin.The Journal of physiology · 2001Article
- Mechanism of inhibition of cyclic nucleotide-gated channel by protein tyrosine kinase probed with genistein.The Journal of general physiology · 2001Article
- Mutation of a single residue in the S2-S3 loop of CNG channels alters the gating properties and sensitivity to inhibitors.The Journal of general physiology · 2000Article
- Mechanism of inhibition of cyclic nucleotide-gated ion channels by diacylglycerol.The Journal of general physiology · 2000Article
- Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein.The Journal of general physiology · 2000Article
- Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina.The Journal of comparative neurology · 2000Article
- The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Activity-dependent modulation of rod photoreceptor cyclic nucleotide-gated channels mediated by phosphorylation of a specific tyrosine residue.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N-terminus of the beta-subunit.The EMBO journal · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrate olfactory sensory neurons, odorant receptors couple the sensory signal to the synthesis of the second messenger cAMP. Cyclic nucleotide-gated (CNG) channels are activated by binding of cAMP and conduct a depolarizing receptor current that leads to electrical excitation of the neuron. The sensitivity of olfactory CNG channels for cAMP can be significantly reduced by binding of calmodulin to a regulatory domain that resides within the N-terminus of the alpha-subunit of the channel. This regulatory domain also contains a consensus phosphorylation sequence for protein kinase C (PKC). We have investigated the effect of channel phosphorylation by PKC and found that phosphorylation increases ligand sensitivity without counteracting modulation of the channel by calmodulin. We have identified the amino acid residue that is phosphorylated by PKC and have localized three isoforms of PKC in olfactory sensory cilia. The results of this study provide information about the control of ligand sensitivity in olfactory CNG channels by an intrinsic regulatory domain, representing both a calmodulin-binding site and a substrate for PKC.
Indexed as
Identifiers
9412497PMC6793416W1869075740What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.