ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 122 citations in OpenAlex.
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- NMNAT2 is a druggable target to drive neuronal NAD production.Nature communications · 2024Article
- Neurog2 regulates Isl1 to modulate horizontal cell number.Development (Cambridge, England) · 2023Article
- Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice.Translational vision science & technology · 2022Article
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- Understanding the retinal basis of vision across species.Nature reviews. Neuroscience · 2020Review
- Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma.Frontiers in genetics · 2020Article
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice.Molecular vision · 2016Article
- The genetic basis of natural variation in mushroom body size in Drosophila melanogaster.Nature communications · 2015Article
- Sex, genetics, and the control of thyroxine and thyrotropin in mice.Thyroid : official journal of the American Thyroid Association · 2014Article
- Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes.Brain, behavior and evolution · 2013Article
- Effects of glaucoma on Chrna6 expression in the retina.Current eye research · 2013Article
- Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina.Molecular vision · 2013Article
- Short-term synaptic plasticity compensates for variability in number of motor neurons at a neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis.Neuroreport · 2012Article
- Undersized dendritic arborizations in retinal ganglion cells of the rd1 mutant mouse: a paradigm of early onset photoreceptor degeneration.The Journal of comparative neurology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Common genetic polymorphisms-as opposed to rare mutations-generate almost all heritable differences in the size and structure of the CNS. Surprisingly, these normal variants have not previously been mapped or cloned in any vertebrate species. In a recent paper (), we suggested that much of the variation in retinal ganglion cell number in mice, and the striking bimodality of strain averages, are caused by one or two quantitative trait loci (QTLs). To test this idea, and to map genes linked to this variable and highly heritable quantitative trait, we have counted ganglion cells in 38 recombinant inbred strains (BXD and BXH) derived from parental strains that have high and low cell numbers. A genome-wide search using simple and composite interval-mapping techniques revealed a major QTL on chromosome (Chr) 11 in a 3 cM interval between Hoxb and Krt1 (LOD = 6.8; genome-wide p = 0.001) and possible subsidiary QTLs on Chr 2 and Chr 8. The Chr 11 locus, neuron number control 1 (Nnc1), accounts for one third of the genetic variance among BXH strains and more than half of that among BXD strains, but Nnc1 has no known effects on brain weight, eye weight, or total retinal cell number. Three strong candidate genes have been mapped previously to the same region as Nnc1. These genes-Rara, Thra, and Erbb2- encode receptors for retinoic acid, thyroxine, and neuregulin, respectively. Each receptor is expressed in the retina during development, and their ligands affect the proliferation or survival of retinal cells.
Indexed as
Identifiers
9412494PMC6793385W2147490548What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.