ArticleThe Journal of cell biology1997
Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 210 citations in OpenAlex.
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- Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers.Exploration of targeted anti-tumor therapy · 2023Article
- DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B.Scientific reports · 2022Article
- Early Transcriptional Changes of Adipose-Derived Stem Cells (ADSCs) in Cell Culture.Medicina (Kaunas, Lithuania) · 2022Article
- Prognostic implications of PPL expression in ovarian cancer.Discover oncology · 2022Article
- Mechanism of periplakin on ovarian cancer cell phenotype and its influence on prognosis.Translational cancer research · 2022Article
- Embryonic developmental arrest in the annual killifish Austrolebias charrua: A proteomic approach to diapause III.PloS one · 2021Article
- Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.Molecular & cellular proteomics : MCP · 2020Article
- A novel prognostic two-gene signature for triple negative breast cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Proteomic Characterization of Urinary Extracellular Vesicles from Kidney-Transplanted Patients Treated with Calcineurin Inhibitors.International journal of molecular sciences · 2020Article
- Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions.eLife · 2020Article
- Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach.Molecules (Basel, Switzerland) · 2020Article
- Skin Protein Profile after Major Weight Loss and Its Role in Body Contouring Surgery.Plastic and reconstructive surgery. Global open · 2019Article
- SUMOylation of periplakin is critical for efficient reorganization of keratin filament network.Molecular biology of the cell · 2019Article
- Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma.Medicine · 2018Article
- Mammalian Plakins, Giant Cytolinkers: Versatile Biological Functions and Roles in Cancer.International journal of molecular sciences · 2018Review
- Microtubule-Actin Crosslinking Factor 1 and Plakins as Therapeutic Drug Targets.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cornified envelope is a layer of transglutaminase cross-linked protein that is assembled under the plasma membrane of keratinocytes in the outermost layers of the epidermis. We have determined the cDNA sequence of one of the proteins that becomes incorporated into the cornified envelope of cultured epidermal keratinocytes, a protein with an apparent molecular mass of 195 kD that is encoded by a mRNA with an estimated size of 6.3 kb. The protein is expressed in keratinizing and nonkeratinizing stratified squamous epithelia and in a number of other epithelia. Expression of the protein is upregulated during the terminal differentiation of epidermal keratinocytes in vivo and in culture. Immunogold electron microscopy was used to demonstrate an association of the 195-kD protein with the desmosomal plaque and with keratin filaments in the differentiated layers of the epidermis. Sequence analysis showed that the 195-kD protein is a member of the plakin family of proteins, to which envoplakin, desmoplakin, bullous pemphigoid antigen 1, and plectin belong. Envoplakin and the 195-kD protein coimmunoprecipitate. Analysis of their rod domain sequences suggests that the formation of both homodimers and heterodimers would be energetically favorable. Confocal immunofluorescent microscopy of cultured epidermal keratinocytes revealed that envoplakin and the 195-kD protein form a network radiating from desmosomes, and we speculate that the two proteins may provide a scaffolding onto which the cornified envelope is assembled. We propose to name the 195-kD protein periplakin.
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