ArticleThe Journal of cell biology1997
Three-dimensional patterns and redistribution of myosin II and actin in mitotic Dictyostelium cells.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Patterning of the cell cortex and the localization of cleavage furrows in multi-nucleate cells.Journal of cell science · 2022Article
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- Cellulose fibrils formation and organisation of cytoskeleton during encystment are essential for Acanthamoeba cyst wall architecture.Scientific reports · 2019Article
- A novel mode of cytokinesis without cell-substratum adhesion.Scientific reports · 2017Article
- A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement.Nature communications · 2015Article
- Cortical factor feedback model for cellular locomotion and cytofission.PLoS computational biology · 2009Article
- Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Directional sensing during chemotaxis.FEBS letters · 2008Review
- Mechanics and regulation of cytokinesis.Current opinion in cell biology · 2004Review
- Novel myosin heavy chain kinase involved in disassembly of myosin II filaments and efficient cleavage in mitotic dictyostelium cells.Molecular biology of the cell · 2002Article
- Quantitation of the distribution and flux of myosin-II during cytokinesis.BMC cell biology · 2002Article
- Real-time visualization of intracellular hydrodynamics in single living cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium discoideum cytokinesis mutant.The Journal of cell biology · 2000Article
- LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium.Molecular biology of the cell · 1999Article
- DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility.The Journal of cell biology · 1999Article
- Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow.The EMBO journal · 1999Article
- The small GTP-binding protein rho regulates cortical activities in cultured cells during division.The Journal of cell biology · 1999Article
- A role for Dictyostelium racE in cortical tension and cleavage furrow progression.The Journal of cell biology · 1998Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin II is not essential for cytokinesis in cells of Dictyostelium discoideum that are anchored on a substrate (Neujahr, R., C. Heizer, and G. Gerisch. 1997. J. Cell Sci. 110:123-137), in contrast to its importance for cell division in suspension (DeLozanne, A., and J.A. Spudich. 1987. Science. 236:1086-1091; Knecht, D.A., and W.F. Loomis. 1987. Science. 236: 1081-1085.). These differences have prompted us to investigate the three-dimensional distribution of myosin II in cells dividing under one of three conditions: (a) in shaken suspension, (b) in a fluid layer on a solid substrate surface, and (c) under mechanical stress applied by compressing the cells. Under the first and second conditions outlined above, myosin II does not form patterns that suggest a contractile ring is established in the furrow. Most of the myosin II is concentrated in the regions that flank the furrow on both sides towards the poles of the dividing cell. It is only when cells are compressed that myosin II extensively accumulates in the cleavage furrow, as has been previously described (Fukui, Y., T.J. Lynch, H. Brzeska, and E.D. Korn. 1989. Nature. 341:328-331), i.e., this massive accumulation is a response to the mechanical stress. Evidence is provided that the stress-associated translocation of myosin II to the cell cortex is a result of the dephosphorylation of its heavy chains. F-actin is localized in the dividing cells in a distinctly different pattern from that of myosin II. The F-actin is shown to accumulate primarily in protrusions at the two poles that ultimately form the leading edges of the daughter cells. This distribution changes dynamically as visualized in living cells with a green fluorescent protein-actin fusion.
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