ArticleThe Journal of cell biology1997
A nuclear import pathway for a protein involved in tRNA maturation.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 85 citations in OpenAlex.
- Karyopherin-mediated nucleocytoplasmic transport.Nature reviews. Molecular cell biology · 2022Review
- Single nucleotide mapping of trait space reveals Pareto fronts that constrain adaptation.Nature ecology & evolution · 2019Article
- Microarray Analysis of Gene Expression in Saccharomyces cerevisiae kap108Δ Mutants upon Addition of Oxidative Stress.G3 (Bethesda, Md.) · 2016Article
- Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review.Cancer metastasis reviews · 2013Review
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Nuclear import by karyopherin-βs: recognition and inhibition.Biochimica et biophysica acta · 2011Review
- Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion.Molecular and cellular biology · 2011Article
- Interaction with the histone chaperone Vps75 promotes nuclear localization and HAT activity of Rtt109 in vivo.Traffic (Copenhagen, Denmark) · 2011Article
- Efficient nuclear transport of structurally disturbed cargo: mutations in a cargo protein switch its cognate karyopherin.PloS one · 2011Article
- An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress.Nucleic acids research · 2010Article
- Nap1 and Chz1 have separate Htz1 nuclear import and assembly functions.Traffic (Copenhagen, Denmark) · 2010Article
- The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus.Nucleic acids research · 2008Article
- The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA.Nucleic acids research · 2007Article
- Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.Molecular and cellular biology · 2006Article
- Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.RNA (New York, N.Y.) · 2005Article
- Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.Molecular biology of the cell · 2004Article
- Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p.Molecular genetics and genomics : MGG · 2004Article
- Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling.Current genetics · 2003Review
- Nuclear import of zinc binuclear cluster proteins proceeds through multiple, overlapping transport pathways.Eukaryotic cell · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A limited number of transport factors, or karyopherins, ferry particular substrates between the cytoplasm and nucleoplasm. We identified the Saccharomyces cerevisiae gene YDR395w/SXM1 as a potential karyopherin on the basis of limited sequence similarity to known karyopherins. From yeast cytosol, we isolated Sxm1p in complex with several potential import substrates. These substrates included Lhp1p, the yeast homologue of the human autoantigen La that has recently been shown to facilitate maturation of pre-tRNA, and three distinct ribosomal proteins, Rpl16p, Rpl25p, and Rpl34p. Further, we demonstrate that Lhp1p is specifically imported by Sxm1p. In the absence of Sxm1p, Lhp1p was mislocalized to the cytoplasm. Sxm1p and Lhp1p represent the karyopherin and a cognate substrate of a unique nuclear import pathway, one that operates upstream of a major pathway of pre-tRNA maturation, which itself is upstream of tRNA export in wild-type cells. In addition, through its association with ribosomal proteins, Sxm1p may have a role in coordinating ribosome biogenesis with tRNA processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.