ArticleThe Journal of clinical investigation1997
Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Hyperlipidemia in membranous nephropathy.Clinical kidney journal · 2026Review
- C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy.Kidney international reports · 2023Article
- The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction.Frontiers in physiology · 2020Review
- PLA2R and THSD7A: Disparate Paths to the Same Disease?Journal of the American Society of Nephrology : JASN · 2017Review
- A podocyte view of membranous nephropathy: from Heymann nephritis to the childhood human disease.Pflugers Archiv : European journal of physiology · 2017Review
- 2015 Homer W. Smith Award: The Podocyte from Periphery to Center Stage.Journal of the American Society of Nephrology : JASN · 2016Review
- Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.The Journal of clinical investigation · 2016Article
- Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease.Journal of the American Society of Nephrology : JASN · 2016Article
- Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.Journal of the American Society of Nephrology : JASN · 2016Article
- Immunopathogenesis of membranous nephropathy: an update.Seminars in immunopathology · 2014Review
- In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye.Scientific reports · 2014Article
- Metabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury.Frontiers in endocrinology · 2014Review
- Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.The Journal of biological chemistry · 2013Article
- Pathogenesis of membranous nephropathy: recent advances and future challenges.Nature reviews. Nephrology · 2012Review
- Glomerular proteinuria: a complex interplay between unique players.Advances in chronic kidney disease · 2011Review
- Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.Journal of the American Society of Nephrology : JASN · 2009Article
- Target antigens and nephritogenic antibodies in membranous nephropathy: of rats and men.Seminars in immunopathology · 2007Review
- Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway.Lipids in health and disease · 2006Article
- Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes.Lipids in health and disease · 2005Article
- Transcobalamin II receptor interacts with megalin in the renal apical brush border membrane.The Journal of membrane biology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Megalin/gp330 is an endocytic receptor that internalizes multiple ligands including apolipoproteins E (apo E) and B100 (apo B). Megalin is the main antigenic target in passive Heymann nephritis (pHN), where it binds circulating autoantibodies leading to the formation of subepithelial immune deposits (ID)-the hallmark of pHN. Apo E and apo B were found recently to accumulate within these IDs, and evidence was provided that their lipids may undergo peroxidation, causing glomerular basement membrane damage and proteinuria. Here we investigated if ID-forming antimegalin IgG can inhibit the binding and internalization of apo E-betaVLDL (very low density lipoprotein) by megalin, and lead to their accumulation within IDs. By immunoelectron microscopy, apo E and apo B were detected in clathrin-coated pits and multivesicular bodies of podocytes in control rats, suggesting that the uptake of lipoproteins is a constitutive function of the glomerular epithelium. When pHN was induced by intravenous injection of antimegalin IgG, apo E and apo B were found within IDs by immunofluorescence and immunoelectron microscopy. Bound antibodies eluted from glomeruli of rats with pHN were found to inhibit the binding and internalization of apo E-enriched betaVLDL by megalin. These results indicate that pHN-inducing antimegalin IgG is capable of interfering with the uptake of lipoproteins by megalin in vivo during the formation of IDs.
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