ArticleThe Journal of clinical investigation1997
Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 230 citations in OpenAlex.
- Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.MedComm · 2025Review
- Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease.Frontiers in cardiovascular medicine · 2022Review
- Protocatechuic acid attenuates isoproterenol-induced cardiac hypertrophy via downregulation of ROCK1-Sp1-PKCγ axis.Scientific reports · 2021Article
- Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Frontiers in pharmacology · 2020Article
- PKC and PKN in heart disease.Journal of molecular and cellular cardiology · 2019Review
- Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.British journal of pharmacology · 2019Article
- Network-based predictions of in vivo cardiac hypertrophy.Journal of molecular and cellular cardiology · 2018Article
- Metabolism in cardiomyopathy: every substrate matters.Cardiovascular research · 2017Review
- Protein kinase C mechanisms that contribute to cardiac remodelling.Clinical science (London, England : 1979) · 2016Review
- Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ.Cellular signalling · 2016Article
- Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.PloS one · 2016Article
- Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.Science signaling · 2015Article
- Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes.Glycobiology · 2014Article
- Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.Cell death & disease · 2014Article
- Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.Basic research in cardiology · 2014Article
- Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions.PloS one · 2013Article
- Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.Scientific reports · 2013Article
- Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.Journal of muscle research and cell motility · 2012Article
- Protein kinase C, an elusive therapeutic target?Nature reviews. Drug discovery · 2012Review
- PKCβII modulation of myocyte contractile performance.Journal of molecular and cellular cardiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Protein kinase C (PKC) activation in the heart has been linked to a hypertrophic phenotype and to processes that influence contractile function. To establish whether PKC activation is sufficient to induce an abnormal phenotype, PKCbeta was conditionally expressed in cardiomyocytes of transgenic mice. Transgene expression in adults caused mild and progressive ventricular hypertrophy associated with impaired diastolic relaxation, whereas expression in newborns caused sudden death associated with marked abnormalities in the regulation of intracellular calcium. Thus, the PKC signaling pathway in cardiocytes has different effects depending on the timing of expression and, in the adult, is sufficient to induce pathologic hypertrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.