ArticleThe Journal of clinical investigation1997
Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.Radiation and environmental biophysics · 2010Pooled it
- CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation.International journal of molecular sciences · 2021Article
- Genetics of Arterial-Wall-Specific Mechanisms in Atherosclerosis: Focus on Mitochondrial Mutations.Current atherosclerosis reports · 2020Review
- Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation.Cardiovascular research · 2019Review
- Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Coding Microsatellite Frameshift Mutations Accumulate in Atherosclerotic Carotid Artery Lesions: Evaluation of 26 Cases and Literature Review.Molecular medicine (Cambridge, Mass.) · 2015Article
- Molecular studies on coronary artery disease-a review.Indian journal of clinical biochemistry : IJCB · 2013Review
- DNA damage and repair in atherosclerosis: current insights and future perspectives.International journal of molecular sciences · 2012Review
- Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects.Cell and tissue research · 2012Review
- Do non-targeted effects increase or decrease low dose risk in relation to the linear-non-threshold (LNT) model?Mutation research · 2010Review
- Role of somatic mutations in vascular disease formation.Expert review of molecular diagnostics · 2010Review
- Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.Journal of biomedical science · 2009Article
- Cholesterol modulates cellular TGF-beta responsiveness by altering TGF-beta binding to TGF-beta receptors.Journal of cellular physiology · 2008Article
- Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.Journal of cell science · 2007Article
- Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
- Disruption of TGF-beta signaling in T cells accelerates atherosclerosis.The Journal of clinical investigation · 2003Article
- Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.The American journal of pathology · 2002Article
- Genomic approaches to research in pulmonary hypertension.Respiratory research · 2001Review
- p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells.The American journal of pathology · 2000Article
- The good smooth muscle cells in atherosclerosis.Current atherosclerosis reports · 2000Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Cells proliferating from human atherosclerotic lesions are resistant to the antiproliferative effect of TGF-beta1, a key factor in wound repair. DNA from human atherosclerotic and restenotic lesions was used to test the hypothesis that microsatellite instability leads to specific loss of the Type II receptor for TGF-beta1 (TbetaR-II), causing acquired resistance to TGF-beta1. High fidelity PCR and restriction analysis was adapted to analyze deletions in an A10 microsatellite within TbetaR-II. DNA from lesions, and cells grown from lesions, showed acquired 1 and 2 bp deletions in TbetaR-II, while microsatellites in the hMSH3 and hMSH6 genes, and hypermutable regions of p53 were unaffected. Sequencing confirmed that these deletions occurred principally in the replication error-prone A10 microsatellite region, though nonmicrosatellite mutations were observed. The mutations could be identified within specific patches of the lesion, while the surrounding tissue, or unaffected arteries, exhibited the wild-type genotype. This microsatellite deletion causes frameshift loss of receptor function, and thus, resistance to the antiproliferative and apoptotic effects of TGF-beta1. We propose that microsatellite instability in TbetaR-II disables growth inhibitory pathways, allowing monoclonal selection of a disease-prone cell type within some vascular lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.