ArticleGenetics1997
Alu evolution in human populations: using the coalescent to estimate effective population size.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Biases in ARG-Based Inference of Historical Population Size in Populations Experiencing Selection.Molecular biology and evolution · 2024Article
- Regulatory activity is the default DNA state in eukaryotes.Nature structural & molecular biology · 2024Article
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- Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine.The Journal of allergy and clinical immunology · 2014Review
- Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping.BMC genomics · 2013Article
- Article
- Upper Pleistocene Human Dispersals out of Africa: A Review of the Current State of the Debate.International journal of evolutionary biology · 2011Article
- Mobile element scanning (ME-Scan) by targeted high-throughput sequencing.BMC genomics · 2010Article
- Mobile elements reveal small population size in the ancient ancestors of Homo sapiens.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans.BMC genomics · 2010Article
- Estimating translational selection in eukaryotic genomes.Molecular biology and evolution · 2009Article
- Intergenic DNA sequences from the human X chromosome reveal high rates of global gene flow.BMC genetics · 2008Article
- Calculating expected DNA remnants from ancient founding events in human population genetics.BMC genetics · 2008Article
- Recent human effective population size estimated from linkage disequilibrium.Genome research · 2007Article
- Modeling the amplification dynamics of human Alu retrotransposons.PLoS computational biology · 2005Article
- Population genetic analysis of ascertained SNP data.Human genomics · 2004Review
- Article
- Article
- Sequence variations in the public human genome data reflect a bottlenecked population history.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.American journal of human genetics · 2002Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are estimated to be approximately 1000 members of the Ya5 Alu subfamily of retroposons in humans. This subfamily has a distribution restricted to humans, with a few copies in gorillas and chimpanzees. Fifty-seven Ya5 elements were previously cloned from a HeLa-derived randomly sheared total genomic library, sequenced, and screened for polymorphism in a panel of 120 unrelated humans. Forty-four of the 57 cloned Alu repeats were monomorphic in the sample and 13 Alu repeats were dimorphic for insertion presence/absence. The observed distribution of sample frequencies of the 13 dimorphic elements is consistent with the theoretical expectation for elements ascertained in a single diploid cell line. Coalescence theory is used to compute expected total pedigree branch lengths for monomorphic and dimorphic elements, leading to an estimate of human effective population size of approximately 18,000 during the last one to two million years.
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