ArticleGenetics1997
Calmodulin point mutations affect Drosophila development and behavior.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026Review
- Norroa™ as a dsRNA biopesticide forFrontiers in insect science · 2026Review
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- NaStructure (London, England : 1993) · 2021Article
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development.G3 (Bethesda, Md.) · 2015Article
- Article
- Intracellular Ca2+ regulates free-running circadian clock oscillation in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.PLoS biology · 2006Article
- Plasticity and second messengers during synapse development.International review of neurobiology · 2006Review
- Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila.Protein science : a publication of the Protein Society · 2004Article
- Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements.Genetics · 2003Article
- Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system.Genetics · 2003Article
- Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Genetic analysis of functional domains within the Drosophila LARK RNA-binding protein.Genetics · 2001Article
- Article
- Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation.The Biochemical journal · 1999Article
- Increased transmitter release and aberrant synapse morphology in a Drosophila calmodulin mutant.Genetics · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Calmodulin (CAM) is recognized as a major intermediary in intracellular calcium signaling, but as yet little is known of its role in developmental and behavioral processes. We have generated and studied mutations to the endogenous Cam gene of Drosophila melanogaster that change single amino acids within the protein coding region. One of these mutations produces a striking pupal lethal phenotype involving failure of head eversion. Various mutant combinations produce specific patterns of ectopic wing vein formation or melanotic scabs on the cuticle. Anaphase chromosome bridging is also seen as a maternal effect during the early embryonic nuclear divisions. In addition, specific behavioral defects such as poor climbing and flightlessness are detected among these mutants. Comparisons with other Drosophila mutant phenotypes suggests potential CAM targets that may mediate these developmental and behavioral effects, and analysis of the CAM crystal structure suggests the structural consequences of the individual mutations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.