ArticleGenes & development1997
The preference for GT-rich DNA by the yeast Rad51 protein defines a set of universal pairing sequences.
Article in Genes & development, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo.BMC genomics · 2018Article
- Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.PloS one · 2016Article
- TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro.Biochemistry · 2014Article
- Article
- Molecular mechanism of sequence-dependent stability of RecA filament.Nucleic acids research · 2013Article
- GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination.Nucleic acids research · 2010Article
- Human Rad51 protein displays enhanced homologous pairing of DNA sequences resembling those at genetically unstable loci.Nucleic acids research · 2006Article
- Probing the DNA sequence specificity of Escherichia coli RECA protein.Nucleic acids research · 2006Article
- (TG/CA)n repeats in human gene families: abundance and selective patterns of distribution according to function and gene length.BMC genomics · 2005Article
- Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.Molecular and cellular biology · 2004Article
- Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets.Nucleic acids research · 2004Article
- Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair.Microbiology and molecular biology reviews : MMBR · 2002Review
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts.Nucleic acids research · 2000Article
- Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.Nucleic acids research · 2000Article
- GT repeats are associated with recombination on human chromosome 22.Genome research · 2000Article
- Yeast cell-free system that catalyses joint-molecule formation in a Rad51p- and Rad52p-dependent fashion.The Biochemical journal · 2000Article
- Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing.The EMBO journal · 2000Article
- Yeast meiosis-specific protein Hop1 binds to G4 DNA and promotes its formation.Molecular and cellular biology · 2000Article
- SELEX_DB: an activated database on selected randomized DNA/RNA sequences addressed to genomic sequence annotation.Nucleic acids research · 2000Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The Rad51 protein of Saccharomyces cerevisiae is a eukaryotic homolog of the RecA protein, the prototypic DNA strand-exchange protein of Escherichia coli. RAD51 gene function is required for efficient genetic recombination and for DNA double-strand break repair. Recently, we demonstrated that RecA protein has a preferential affinity for GT-rich DNA sequences-several of which exhibit enhanced RecA protein-promoted homologous pairing activity. The fundamental similarity between the RecA and Rad51 proteins suggests that Rad51 might display an analogous bias. Using in vitro selection, here we show that the yeast Rad51 protein shares the same preference for GT-rich sequences as its prokaryotic counterpart. This bias is also manifest as an increased ability of Rad51 protein to promote the invasion of supercoiled DNA by homologous GT-rich single-stranded DNA, an activity not previously described for the eukaryotic pairing protein. We propose that the preferred utilization of GT-rich sequences is a conserved feature among all homologs of RecA protein, and that GT-rich regions are loci for increased genetic exchange in both prokaryotes and eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.