ArticleMolecular and cellular biochemistry1997
Activation of the neutrophil and loss of plasma glutathione during Mg-deficiency--modulation by nitric oxide synthase inhibition.
Article in Molecular and cellular biochemistry, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Role of Magnesium in the Intensive Care Unit and Immunomodulation: A Literature Review.Vaccines · 2023Review
- Physical Gold Nanoparticle-Decorated Polyethylene Glycol-Hydroxyapatite Composites Guide Osteogenesis and Angiogenesis of Mesenchymal Stem Cells.Biomedicines · 2021Article
- Hepatic Response of Magnesium-Restricted Wild Type Mice.Metabolites · 2021Article
- Article
- Magnesium enhances the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation.Scientific reports · 2018Article
- Magnesium and cardiovascular complications of chronic kidney disease.Nature reviews. Nephrology · 2015Review
- Article
- Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: Protection by substance P receptor blockade.Experimental and clinical cardiology · 2011Article
- Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia.The American journal of the medical sciences · 2009Review
- Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium.Cardiovascular research · 2009Review
- Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2008Article
- Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function.Molecular and cellular biochemistry · 2007Article
- The nerve-heart connection in the pro-oxidant response to Mg-deficiency.Heart failure reviews · 2006Review
- Possible roles of magnesium on the immune system.European journal of clinical nutrition · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Sprague-Dawley rats (200 g) were fed either a Mg-deficient or Mg-sufficient diet for 3 weeks. An enriched neutrophil fraction (> 85%) was isolated from the blood by sodium metrizoate/dextran gradient centrifugation. Using the superoxide dismutase. (SOD)-inhibitable cytochrome c reduction assay, the basal activity of neutrophils isolated from the Mg-deficient rats were found elevated 5 fold after two weeks, and up to approximately 7 fold after three weeks on the diet. Upon challenge by phorbol myristate acetate (PMA), unlike the Mg-sufficient cells, the Mg-deficient cells exhibited no significant activation. Treatment of the Mg-deficient rats with the nitric oxide (NO)-synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) in the drinking water, significantly attenuated the basal superoxide producing activity of the neutrophils and partially restored its response to PMA challenge. In association with the neutrophil activation. Mg-deficiency resulted in 70% decrease in plasma glutathione and 220% increase in Fe-promoted, thiobarbituric acid reactive substance (TBARS) levels; both changes were significantly attenuated by L-NAME treatment. The results suggest that neutrophils from Mg-deficient rats are activated endogenously to generate oxy-radicals which might directly mediate the in vivo peroxidative indices during Mg-deficiency. Furthermore, the neutrophil activity was lowered by NO-synthase inhibition suggesting that NO overproduction during Mg-deficiency participates in the neutrophil activation process.
Indexed as
Identifiers
9406142W1846038984What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.