ArticleProceedings of the National Academy of Sciences of the United States of America1997
Hair cell-specific splicing of mRNA for the alpha1D subunit of voltage-gated Ca2+ channels in the chicken's cochlea.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.Life science alliance · 2020Article
- Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Article
- Alternative splicing of voltage-gated calcium channels: from molecular biology to disease.Pflugers Archiv : European journal of physiology · 2009Review
- Sparc protein is required for normal growth of zebrafish otoliths.Journal of the Association for Research in Otolaryngology : JARO · 2008Article
- Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells.The Journal of physiology · 2008Article
- Development and regeneration of hair cells share common functional features.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken.The Journal of physiology · 2007Article
- Ion channel gene expression in the inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
- Alternative splicing of the Ca(v)1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients.The Journal of physiology · 2004Article
- Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice.Journal of the Association for Research in Otolaryngology : JARO · 2004Article
- Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Biophysical and pharmacological characterization of voltage-gated calcium currents in turtle auditory hair cells.The Journal of physiology · 2003Article
- Effects of permeant ion concentrations on the gating of L-type Ca2+ channels in hair cells.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The L-type voltage-gated Ca2+ channels that control tonic release of neurotransmitter from hair cells exhibit unusual electrophysiological properties: a low activation threshold, rapid activation and deactivation, and a lack of Ca2+-dependent inactivation. We have inquired whether these characteristics result from cell-specific splicing of the mRNA for the L-type alpha1D subunit that predominates in hair cells of the chicken's cochlea. The alpha1D subunit in hair cells contains three uncommon exons: one encoding a 26-aa insert in the cytoplasmic loop between repeats I and II, an alternative exon for transmembrane segment IIIS2, and a heretofore undescribed exon specifying a 10-aa insert in the cytoplasmic loop between segments IVS2 and IVS3. We propose that the alternative splicing of the alpha1D mRNA contributes to the unusual behavior of the hair cell's voltage-gated Ca2+ channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.