ArticleProceedings of the National Academy of Sciences of the United States of America1997
Block of transmitter release by botulinum C1 action on syntaxin at the squid giant synapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission.Advances in neurobiology · 2023Review
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- Open syntaxin docks synaptic vesicles.PLoS biology · 2007Article
- Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.PLoS biology · 2007Article
- Docking of secretory vesicles is syntaxin dependent.PloS one · 2006Article
- Activity-dependent excitability changes in hippocampal CA3 cell Schaffer axons.The Journal of physiology · 2004Article
- Defects in synaptic vesicle docking in unc-18 mutants.Nature neuroscience · 2003Article
- Regulation of exocytosis through Ca2+/ATP-dependent binding of autophosphorylated Ca2+/calmodulin-activated protein kinase II to syntaxin 1A.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Enhancement of presynaptic calcium current by cysteine string protein.The Journal of physiology · 2002Article
- SNARE proteins contribute to calcium cooperativity of synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Syntaxin modulation of slow inactivation of N-type calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Proteins involved in synaptic vesicle trafficking.The Journal of physiology · 1999Review
- Syntaxin is required for cell division.Molecular biology of the cell · 1999Article
- Presynaptic frequency- and pattern-dependent filtering.Journal of computational neuroscienceReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Electrophysiological, morphological, and biochemical approaches were combined to study the effect of the presynaptic injection of the light chain of botulinum toxin C1 into the squid giant synapse. Presynaptic injection was accompanied by synaptic block that occurred progressively as the toxin filled the presynaptic terminal. Neither the presynaptic action potential nor the Ca2+ currents in the presynaptic terminal were affected by the toxin. Biochemical analysis of syntaxin moiety in squid indicates that the light chain of botulinum toxin C1 lyses syntaxin in vitro, suggesting that this was the mechanism responsible for synaptic block. Ultrastructure of the injected synapses demonstrates an enormous increase in the number of presynaptic vesicles, suggesting that the release rather than the docking of vesicles is affected by biochemical lysing of the syntaxin molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.