ArticleProceedings of the National Academy of Sciences of the United States of America1997
Genetically determined chloride-sensitive hypertension and stroke.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Nomogram and scoring models based on BMI z-score, serum chlorine and urine specific gravity levels for predicting oral rehydration solution efficacy in pediatric postural orthostatic tachycardia syndrome.World journal of pediatrics : WJP · 2025Article
- Pendrin: linking acid base to blood pressure.Pflugers Archiv : European journal of physiology · 2024Review
- Chloride Ions, Vascular Function and Hypertension.Biomedicines · 2022Review
- Effect of Oral Sodium Bicarbonate Treatment on 24-Hour Ambulatory Blood Pressure Measurements in Patients With Chronic Kidney Disease and Metabolic Acidosis.Frontiers in medicine · 2021Article
- Re-evaluation of hydrochloric acid (E 507), potassium chloride (E 508), calcium chloride (E 509) and magnesium chloride (E 511) as food additives.EFSA journal. European Food Safety Authority · 2019Article
- SymbiosalEFSA journal. European Food Safety Authority · 2018Article
- Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.American journal of physiology. Renal physiology · 2016Article
- Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced Hypertension.Circulation · 2016Review
- Activation of mineralocorticoid receptor in salt-sensitive hypertension.Current hypertension reports · 2015Review
- The hidden hand of chloride in hypertension.Pflugers Archiv : European journal of physiology · 2015Review
- Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension.Journal of the American Society of Nephrology : JASN · 2013Article
- The role of the kidney in salt-sensitive hypertension.Clinical and experimental nephrology · 2012Review
- Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis.Journal of hypertension · 2010Article
- NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.Journal of veterinary science · 2009Article
- What effect does potassium have on blood pressure?Journal of clinical hypertension (Greenwich, Conn.) · 2008Article
- Sodium-selective salt sensitivity: its occurrence in blacks.Hypertension (Dallas, Tex. : 1979) · 2007Article
- Hypertensive renal damage: insights from animal models and clinical relevance.Current hypertension reports · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetically determined model of "salt-sensitive" stroke and hypertension whose full phenotypic expression is said to require a diet high in Na+ and low in K+. We tested the hypothesis that dietary Cl- determines the phenotypic expression of the SHRSP. In the SHRSP fed a normal NaCl diet, supplementing dietary K+ with KCl exacerbated hypertension, whereas supplementing either KHCO3 or potassium citrate (KB/C) attenuated hypertension, when blood pressure (BP) was measured radiotelemetrically, directly and continually. Supplemental KCl, but not KB/C, induced strokes, which occurred in all and only those rats in the highest quartiles of both BP and plasma renin activity (PRA). PRA was higher with KCl than with KB/C. These observations demonstrate that with respect to both severity of hypertension and frequency of stroke the phenotypic expression of the SHRSP is (i) either increased or decreased, depending on whether the anionic component of the potassium salt supplemented is, or is not, Cl-; (ii) increased by supplementing Cl- without supplementing Na+, and despite supplementing K+; and hence (iii) both selectively Cl--sensitive and Cl--determined. The observations suggest that in the SHRSP selectively supplemented with Cl- the likelihood of stroke depends on the extent to which both BP and PRA increase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.