ArticleProceedings of the National Academy of Sciences of the United States of America1997
Identification and characterization of a human protein kinase related to budding yeast Cdc7p.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives.Communications biology · 2026Review
- GmCDC7 is involved in coordinating seed size and quality in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell Activation.Frontiers in immunology · 2019Article
- DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.Nucleic acids research · 2016Article
- Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.Diagnostic pathology · 2015Article
- ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress.Genes & development · 2013Article
- Expression of huCdc7 in colorectal cancer.World journal of gastroenterology · 2013Article
- Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition.The Journal of biological chemistry · 2011Article
- Chk1 promotes replication fork progression by controlling replication initiation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.Eukaryotic cell · 2005Article
- Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.The EMBO journal · 2003Article
- Drf1, a novel regulatory subunit for human Cdc7 kinase.The EMBO journal · 2002Article
- Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro.Molecular and cellular biology · 2002Article
- Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death.The EMBO journal · 2002Article
- Xenopus Cdc6 performs separate functions in initiating DNA replication.Molecular biology of the cell · 2002Article
- Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.Molecular and cellular biology · 2002Article
- Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.Molecular biology of the cell · 2001Article
- Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.Genes & development · 2000Article
- Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.Molecular and cellular biology · 2000Article
- Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Cdc7p protein kinase is essential for the G1/S transition and initiation of DNA replication during the cell division cycle in Saccharomyces cerevisiae. Cdc7p appears to be an evolutionarily conserved protein, since a homolog Hsk1 has been isolated from Schizosaccharomyces pombe. Here, we report the isolation of a human cDNA, HsCdc7, whose product is closely related in sequence to Cdc7p and Hsk1. The HsCdc7 cDNA encodes a protein of 574 amino acids with predicted size of 64 kDa. HsCdc7 contains the conserved subdomains common to all protein-serine/threonine kinases and three "kinase inserts" that are characteristic of Cdc7p and Hsk1. Immune complexes of HsCdc7 from cell lysates were able to phosphorylate histone H1 in vitro. Indirect immunofluorescence staining demonstrated that HsCdc7 protein was predominantly localized in the nucleus. Although the expression levels of HsCdc7 appeared to be constant throughout the cell cycle, the protein kinase activity of HsCdc7 increased during S phase of the cell cycle at approximately the same time as that of Cdk2. These results, together with the functions of Cdc7p in yeast, suggest that HsCdc7 may phosphorylate critical substrate(s) that regulate the G1/S phase transition and/or DNA replication in mammalian cells.
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