ArticleThorax1997
Relation of fetal growth to adult lung function in south India.
Article in Thorax, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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45 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.
- Pooled it
- Effects of antenatal multiple micronutrient supplementation on lung function in mid-childhood: follow-up of a double-blind randomised controlled trial in Nepal.The European respiratory journal · 2015Trial
- Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model.Scientific reports · 2023Article
- Long-term implications of fetal growth restriction.World journal of clinical cases · 2023Review
- Poor early childhood growth is associated with impaired lung function: Evidence from a Ghanaian pregnancy cohort.Pediatric pulmonology · 2022Article
- Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases.Frontiers in medicine · 2021Review
- Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study.Respiratory research · 2019Article
- Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study.Respiratory research · 2017Article
- Article
- Reduced Forced Vital Capacity in an African Population. Prevalence and Risk Factors.Annals of the American Thoracic Society · 2017Article
- Article
- Relationship between birth weight, maternal smoking during pregnancy and childhood and adolescent lung function: A path analysis.Respiratory medicine · 2016Article
- Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function.Biological research for nursing · 2016Article
- Alcohol-Induced Developmental Origins of Adult-Onset Diseases.Alcoholism, clinical and experimental research · 2016Review
- Challenges in Collating Spirometry Reference Data for South-Asian Children: An Observational Study.PloS one · 2016Observational
- Cohort Profile: The 1934-66 Mysore Birth Records Cohort in South India.International journal of epidemiology · 2015Article
- Disparities in pulmonary function in healthy children across the Indian urban-rural continuum.American journal of respiratory and critical care medicine · 2015Article
- Article
- Do mismatches between pre- and post-natal environments influence adult physiological functioning?PloS one · 2014Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFollow up studies in Britain have shown that low rates of fetal growth are followed by reduced lung function in adult life, independent of smoking and social class. It is suggested that fetal adaptations to undernutrition in utero result in permanent changes in lung structure, which in turn lead to chronic airflow obstruction. India has high rates of intrauterine growth retardation, but no study has examined the association between fetal growth and adult lung function in Indian people. We have related size at birth to lung function in an urban Indian population aged 38-59 years.
methodsTwo hundred and eighty six men and women born in one hospital in Mysore City, South India, during 1934-1953 were traced by a house-to-house survey of the city. Their mean forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured using a turbine spirometer. These measurements were linked to their size at birth, recorded at the time.
resultsIn both men and women mean FEV1 fell with decreasing birthweight. Adjusted for age and height, it fell by 0.09 litres with each pound (454 g) decrease in birthweight in men (95% confidence interval (CI) 0.01 to 0.16) and by 0.06 (95% CI -0.01 to 0.13) in women. Likewise, mean FVC fell by 0.11 litres (95% CI 0.02 to 0.19) with each pound decrease in birthweight in men, and by 0.08 litres (95% CI 0.002 to 0.16) in women. FEV1 and FVC were lower in men who smoked, but the associations with size at birth were independent of smoking. Small head circumference at birth was associated with a low FEV1/FVC ratio in men which may reflect restriction in airway growth in early gestation.
conclusionThis is further evidence that adult lung function is "programmed" in fetal life. Smoking may be particularly detrimental to the lung function of populations already disadvantaged by poor rates of fetal growth.
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