ArticleThe American journal of pathology1997
CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 68 citations in OpenAlex.
- A favorable follicular helper CD4+ T cell programming characterizes neutralization activity in chronic HIV infection.The Journal of clinical investigation · 2026Article
- Dissociation method influences immune cell composition in porcine tonsil cell suspensions.Frontiers in immunology · 2026Article
- Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis.Frontiers in medicine · 2022Article
- Exploring human splenic red pulp vasculature in virtual reality: details of sheathed capillaries and the open capillary network.Histochemistry and cell biology · 2021Article
- Cellular distribution of the prion protein in palatine tonsils of mule deer (Odocoileus hemionus) and Rocky Mountain elk (Cervus elaphus nelsoni).The Journal of veterinary medical science · 2019Article
- Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph Nodes.Frontiers in immunology · 2018Article
- Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma.International journal of clinical and experimental pathology · 2014Review
- Protective role of interferon regulatory factor 3-mediated signaling against prion infection.Journal of virology · 2012Article
- The follicular dendritic cell network in secondary follicles of human palatine tonsils and spleens.Histochemistry and cell biology · 2011Article
- Tertiary lymphoid organs in lymphatic malformations.Lymphatic research and biology · 2011Article
- Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes.Histochemistry and cell biology · 2006Article
- Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use.Journal of clinical pathology · 2004Article
- Follicular dendritic reticulum cell tumor mimicking inflammatory pseudotumor of the spleen.Pathology oncology research : POR · 2004Article
- Potential viral pathogenic mechanism for new variant inflammatory bowel disease.Molecular pathology : MP · 2002Article
- Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new monoclonal antibody (MAb), CNA.42, was generated using the CEM T-cell line. It recognizes a 120-kd formalin-resistant glycosylated antigen that is mainly expressed by follicular dendritic reticulum cells (FDRCs). This antigen is also expressed by a few mononuclear cells in the paracortical area of reactive lymph nodes and by some cortical thymocytes. Two hundred and eighty-nine cases of hematopoietic tumors of various types were tested with this antibody. They showed either intact FDRC networks or FDRC networks dispersed among malignant cells. In follicular lymphomas, the follicular pattern was highlighted by CNA.42 MAb. Expanded FDRC networks were found in angioimmunoblastic T-cell lymphomas. Neoplastic cells were positive in 43.6% (24/55) of T-cell and 4.6% (6/129) of B-cell lymphomas. The highest percentage of cases with positive neoplastic cells was found in anaplastic large-cell lymphomas (62.5%; 15/24). In Hodgkin's disease, FDRC networks, sometimes encasing Hodgkin and Reed-Sternberg (HRS) cells, were found. HRS cells were also stained by this antibody in 23 (21.9%) of the 105 cases examined. A variety of normal nonlymphoid tissues and nonhematopoietic tumors, such as some neurogenic tumors, carcinoma, and occasional sarcomas, were found to be positive. Analysis of the reactivity of CNA.42 antibody with FDRCs of lymphoid tissue from different animal species showed similar reactivity to that observed in humans, suggesting widespread evolutionary conservation of the antigen recognized by this antibody. In daily diagnostic practice, CNA.42 MAb seems to be a suitable FDRC marker and possibly has an auxiliary role in recognizing T-cell lymphomas.
Indexed as
Identifiers
9403709PMC1858341W1823694856What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.