ArticleBritish journal of cancer1997
Allelotype analysis of adenocarcinoma of the gastric cardia.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer.Oncology letters · 2017Article
- MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1.Molecular biology of the cell · 2012Article
- High polymorphism in the trisomic portion of a gastric cancer cell line.Journal of gastroenterology · 2007Article
- A new mixture model approach to analyzing allelic-loss data using Bayes factors.BMC bioinformatics · 2004Article
- Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: in special reference to China.World journal of gastroenterology · 2003Review
- Molecular cytogenetic evaluation of gastric cardia adenocarcinoma and precursor lesions.The American journal of pathology · 2001Article
- Molecular biology of Barrett's adenocarcinoma.Annals of surgery · 2001Review
- Chromosomal alterations in paired gastric adenomas and carcinomas.The American journal of pathology · 2001Article
- Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays.Genome research · 2000Article
- Chromosome band 16q24 is frequently deleted in human gastric cancer.British journal of cancer · 1999Article
- Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.British journal of cancer · 1999Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
To identify chromosomal loci involved in the development of proximal gastric adenocarcinoma, this study delineated the pattern of allelic imbalance in a series of 38 adenocarcinomas arising in the gastric cardia. A total of 137 microsatellite markers covering all autosomal arms, excluding acrocentric arms, were analysed. A mean of 35 out of a total of 39 chromosomal arms studied were informative for each patient. The tumour group demonstrated a high level of allelic imbalance, with an observed median fractional allelic imbalance of 0.47 for the 29 intestinal-type adenocarcinomas and 0.54 for the nine diffuse-type adenocarcinomas. Allelic imbalance was detected in >50% of informative cases in both histological subtypes on a number of chromosomal arms. In the intestinal subtype, these included, 3p (61%), 4q (71%), 5q (59%), 8p (60%), 9p (65%), 9q (83%), 12q (52%), 13q (52%), 17p (78%) and 18q (70%). A higher incidence of allelic imbalance was detected on chromosome 16q in tumours of the diffuse type relative to those of the intestinal type. A more detailed mapping on chromosomes 4q and 6q identified a number of cases with subchromosomal breakpoints. In conclusion, this analysis has indicated regions of the genome potentially involved in the development of proximal gastric carcinomas.
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