ReviewEnvironmental health perspectives1997
The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates.
Review in Environmental health perspectives, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Outdoor air pollutants and asthma risk in adolescents: evidence from a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
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- Anti-inflammatory effects ofToxicological research · 2023Article
- Implications of the Immune Landscape in COPD and Lung Cancer: Smoking Versus Other Causes.Frontiers in immunology · 2022Review
- Polysaccharides From the Aerial Parts ofFrontiers in pharmacology · 2022Article
- The effect of feed supplementation with Transcarpathian zeolite (clinoptilolite) on the concentrations of acute phase proteins and cytokines in the serum and hepatic tissue of chickens.Poultry science · 2020Article
- The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective.Journal of immunology research · 2020Review
- Exposure to PMLipids in health and disease · 2019Article
- Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes.Cancer science · 2018Article
- Cardiovascular Effects of Long-Term Exposure to Air Pollution: A Population-Based Study With 900 845 Person-Years of Follow-up.Journal of the American Heart Association · 2017Article
- Effect of physicochemical character differences on the genotoxic potency of kaolin.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2017Article
- Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms.International journal of environmental research and public health · 2013Review
- Potential toxicity and safety evaluation of nanomaterials for the respiratory system and lung cancer.Lung Cancer (Auckland, N.Z.) · 2013Review
- Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.PloS one · 2012Article
- Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells.Particle and fibre toxicology · 2009Article
- In vitro effects of nanoparticles on renal cells.Particle and fibre toxicology · 2008Article
- Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis.Journal of neurovirology · 2008Article
- The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.Free radical biology & medicine · 2008Review
- Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells.FEBS letters · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiologic and occupational studies indicate adverse health effects due to inhalation of particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully established. The tracheobronchial epithelium forms the body's first physiologic barrier to such airborne pollutants, where ciliary movement functions to remove the offending substances caught in the overlying mucus layer. Resident and infiltrating phagocytic cells also function in this removal process. In this paper, we examine the role of reactive oxygen and nitrogen species (ROS/RNS) in the response of airway epithelium to particulates. Some particulates themselves can generate ROS, as can the epithelial cells, in response to appropriate stimulation. In addition, resident macrophages in the airways and the alveolar spaces can release ROS/RNS after phagocytosis of inhaled particles. These macrophages also release large amounts of tumor necrosis factor alpha (TNF-alpha), a cytokine that can generate responses within the airway epithelium dependent upon intracellular generation of ROS/RNS. As a result, signal transduction pathways are set in motion that may contribute to inflammation and other pathobiology in the airway. Such effects include increased expression of intercellular adhesion molecule 1, interleukin-6, cytosolic and inducible nitric oxide synthase, manganese superoxide dismutase, cytosolic phospholipase A2, and hypersecretion of mucus. Ultimately, ROS/RNS may play a role in the global response of the airway epithelium to particulate pollutants via activation of kinases and transcription factors common to many response genes. Thus, defense mechanisms involved in responding to offending particulates may result in a complex cascade of events that can contribute to airway pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.