Evidence map›Paper›PMID 9399966›Full record

ArticleThe Journal of clinical investigation1997

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

F D Martinez, P E Graves, M Baldini, S Solomon, R Erickson

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 121 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 6 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005475 completednot on this map

Longitudinal Study of Asthma From Birth to Adulthood

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1996 to 2006ConditionsAsthma, Lung Diseases
NCT03926741 early_phase1completednot on this mapstarted 2019, after this paper: background citation

Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge

TypeinterventionalSponsorJames ReynoldsRan2019 to 2024Enrolled48ConditionsAsthmaArmsGSNO Challenge
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 6 syntheses or guidelines pooled it, 610 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Association of polymorphisms in the beta-2 adrenergic receptor gene with fracture risk and bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. beta-Adrenergic receptor polymorphisms and response to salmeterol.American journal of respiratory and critical care medicine · 2006
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Article
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

F D MartinezRespiratory Sciences Center, the University of Arizona College of Medicine, Tucson, Arizona 85724, USA. fernando@resp-sci.arizona.edu
P E Graves
M Baldini
S Solomon
R Erickson
University of Arizona · USChildren's Center · US

Funding

Natural History of Asthma from Birth to Early Adult LifeR01HL056177 · NHLBI · UNIVERSITY OF ARIZONA · PI GUERRA, STEFANO, MARTINEZ, FERNANDO D · 1996 to 2015
$14.4M
TUSCON EPIDEMIOLOGICAL STUDY OF AIRWAYS OBSTRUCTIVE DISEASEP50HL014136 · NHLBI · UNIVERSITY OF ARIZONA · PI HALONEN, MARILYN J · 1985 to 1996
–
NHLBI NIH HHS HL03154NHLBI NIH HHS HL14136NHLBI NIH HHS HL56177
6 · The paper itself

Abstract

The beta2-adrenergic receptor (beta2AR) agonists are the most widely used agents in the treatment of asthma, but the genetic determinants of responsiveness to these agents are unknown. Two polymorphic loci within the coding region of the beta2AR have been recently described at amino acids 16 and 27. It has been reported that glycine at codon 16 (Gly-16) is associated with increased agonist-promoted downregulation of the beta2AR as compared with arginine-16 (Arg-16). The form of the receptor with glutamic acid at codon 27 (Glu-27), on the other hand, has been shown to be resistant to downregulation when compared with glutamine-27 (Gln-27), but only when coexpressed with Arg-16. To assess if different genotypes of these two polymorphisms would show differential responses to inhaled beta2AR agonists, we genotyped 269 children who were participants in a longitudinal study of asthma. Spirometry was performed before and after administration of 180 microg of albuterol, and a positive response was considered an increase of >15.3% predicted FEV1. There was marked linkage disequilibrium between the two polymorphisms, with 97.8% of all chromosomes that carried Arg-16 also carrying Gln-27. When compared to homozygotes for Gly-16, homozygotes for Arg-16 were 5.3 times (95% confidence interval 1.6-17.7) and heterozygotes for beta2AR-16 were 2.3 times (1.3-4.2) more likely to respond to albuterol, respectively. Similar trends were observed for asthmatic and nonasthmatic children, and results were independent of baseline lung function, ethnic origin, and previous use of antiasthma medication. No association was found between the beta2AR-27 polymorphism and response to albuterol. These results may explain some of the variability in response to therapeutic doses of albuterol in children.

Indexed as

Polymorphism, GeneticAdrenergic beta-AgonistsAlbuterolAllelesArginineAsthmaBronchodilator AgentsChildGlutamic AcidGlutamineGlycineHumansLinkage DisequilibriumLongitudinal StudiesReceptors, Adrenergic, beta-2Respiratory SoundsAdrenergic beta-AgonistsAlbuterolArginineBronchodilator AgentsGlutamic AcidGlutamineGlycineReceptors, Adrenergic, beta-2

Identifiers

PMID9399966
PMCPMC508532
OpenAlexW2015371796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.