ArticleThe Journal of clinical investigation1997
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 171 citations in OpenAlex.
- The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation.Frontiers in immunology · 2025Article
- CTSS contributes to airway neutrophilic inflammation in mixed granulocytic asthma.Respiratory research · 2024Article
- Asthma-protective agents in dust from traditional farm environments.The Journal of allergy and clinical immunology · 2023Article
- Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.Cell host & microbe · 2021Article
- Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity.Mediators of inflammation · 2018Article
- Lung-Infiltrating Foxp3Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge.JCI insight · 2017Article
- Targeting eosinophils in allergy, inflammation and beyond.Nature reviews. Drug discovery · 2013Review
- Key role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.PloS one · 2013Article
- Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.PloS one · 2013Article
- Novel targeted therapies for eosinophilic disorders.The Journal of allergy and clinical immunology · 2012Review
- Resveratrol-mediated gamma interferon reduction prevents airway inflammation and airway hyperresponsiveness in respiratory syncytial virus-infected immunocompromised mice.Journal of virology · 2011Article
- A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells.Clinical and experimental immunology · 2011Article
- Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity.The American journal of pathology · 2010Article
- Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.Experimental hematology · 2009Article
- Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid.Journal of proteome research · 2009Article
- An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice.European journal of pharmacology · 2009Article
- The role of epithelial integrin receptors in recognition of pulmonary pathogens.Journal of innate immunity · 2009Review
- Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.Journal of leukocyte biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Immunized mice after inhalation of specific antigen have the following characteristic features of human asthma: airway eosinophilia, mucus and Th2 cytokine release, and hyperresponsiveness to methacholine. A model of late-phase allergic pulmonary inflammation in ovalbumin-sensitized mice was used to address the role of the alpha4 integrin (CD49d) in mediating the airway inflammation and hyperresponsiveness. Local, intrapulmonary blockade of CD49d by intranasal administration of CD49d mAb inhibited all signs of lung inflammation, IL-4 and IL-5 release, and hyperresponsiveness to methacholine. In contrast, CD49d blockade on circulating leukocytes by intraperitoneal CD49d mAb treatment only prevented the airway eosinophilia. In this asthma model, a CD49d-positive intrapulmonary leukocyte distinct from the eosinophil is the key effector cell of allergen-induced pulmonary inflammation and hyperresponsiveness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.