ArticleThe Journal of clinical investigation1997
Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- KArhiv za farmaciju · 2024Article
- Subcellular trafficking and endocytic recycling of KAmerican journal of physiology. Cell physiology · 2022Review
- Localization of ATP-sensitive KWorld journal of experimental medicine · 2019Article
- Synthetic CpG oligonucleotides induce a genetic profile ameliorating murine myocardial I/R injury.Journal of cellular and molecular medicine · 2018Article
- The beneficial effect of repaglinide on in vitro maturation and development ability of immature mouse oocytes.In vitro cellular & developmental biology. Animal · 2017Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Diazoxide preconditioning antagonizes cytotoxicity induced by epileptic seizures.Neural regeneration research · 2013Article
- Molecular basis and structural insight of vascular K(ATP) channel gating by S-glutathionylation.The Journal of biological chemistry · 2011Article
- Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats.Acta pharmacologica Sinica · 2011Article
- Human oocytes express ATP-sensitive K(+) channels.Human reproduction (Oxford, England) · 2010Article
- Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂.Neurochemical research · 2009Article
- Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.Trends in cardiovascular medicine · 2009Review
- Effects of Abeta1-42 on the subunits of KATP expression in cultured primary rat basal forebrain neurons.Neurochemical research · 2008Article
- ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2005Article
- Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature.BMC physiology · 2005Article
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
- Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.International journal of impotence research · 2003Article
- Sinus Node Dysfunction in Atrial Fibrillation: Cause or Effect?Journal of atrial fibrillationReview
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cardiac ATP-sensitive potassium (KATP) channel is thought to be a complex composed of an inward rectifier potassium channel (Kir6.1 and/or Kir6.2) subunit and the sulfonylurea receptor (SUR2). This channel is activated during myocardial ischemia and protects the heart from ischemic injury. We examined the transcriptional expression of these genes in rats with myocardial ischemia. 60 min of myocardial regional ischemia followed by 24-72 h, but not 3-6 h, of reperfusion specifically upregulated Kir6.1 mRNA not only in the ischemic (approximately 2.7-3.1-fold) but also in the nonischemic (approximately 2.0-2.6-fold) region of the left ventricle. 24 h of continuous ischemia without reperfusion also induced an increase in Kir6.1 mRNA in both regions, whereas 15-30 min of ischemia followed by 24 h of reperfusion did not induce such expression. In contrast, mRNAs for Kir6.2 and SUR2 remained unchanged under these ischemic procedures. Western blotting demonstrated similar increases in the Kir6.1 protein level both in the ischemic (2.4-fold) and the nonischemic (2.2-fold) region of rat hearts subjected to 60 min of ischemia followed by 24 h of reperfusion. Thus, prolonged myocardial ischemia rather than reperfusion induces delayed and differential regulation of cardiac KATP channel gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.