ArticleAmerican journal of human genetics1997
Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 101 citations in OpenAlex.
- Family-based designs for genome-wide association studies.Nature reviews. Genetics · 2011Review
- Haseman-Elston regression in ascertained samples: importance of dependent variable and mean correction factor selection.Human heredity · 2008Article
- A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.Molecular and cellular neurosciences · 2007Article
- Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q.Molecular psychiatry · 2006Article
- Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26.American journal of human genetics · 2005Article
- Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease.Journal of medical genetics · 2004Article
- Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?BMC genetics · 2003Article
- Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs.American journal of human genetics · 2003Article
- The power and statistical behaviour of allele-sharing statistics when applied to models with two disease loci.Journal of genetics · 2002Article
- Genetics of diabetic nephropathy in the Pima Indians.Current diabetes reports · 2001Review
- A survey of affected-sibship statistics for nonparametric linkage analysis.American journal of human genetics · 2001Article
- Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.American journal of human genetics · 2000Article
- Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.American journal of human genetics · 2000Article
- Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.American journal of human genetics · 2000Article
- A genome screen of multiplex sibships with prostate cancer.American journal of human genetics · 2000Article
- A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.American journal of human genetics · 1999Article
- Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.American journal of human genetics · 1999Article
- Genome scan for human obesity and linkage to markers in 20q13.American journal of human genetics · 1999Article
- Further evidence for the increased power of LOD scores compared with nonparametric methods.American journal of human genetics · 1999Article
- Tests and estimates of allelic association in complex inheritance.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
We have evaluated 23 different statistics, from a total of 10 popular software packages for model-free linkage analysis of nuclear-family data, by applying them to single-marker data simulated under several two-locus disease models. The statistics that we examined fall into two broad categories: (1) those that test directly for increased identity-by-state or identity-by-descent sharing (by use of the programs APM, Genetic Analysis System [GAS] SIBSTATE and SIBDES, SAGE SIBPAL, ERPA, SimIBD, and Genehunter NPL) and (2) those that are based on likelihood-ratio tests and that report LOD scores (by use of the programs Splink, SIBPAIR, Mapmaker/Sibs, ASPEX, and GAS SIBMLS). For each of eight two-locus disease models, we analyzed six data sets; the first three data sets consisted of two-child families with both sibs affected and zero, one, or both parents typed, whereas the other three data sets consisted of four-child families with at least two affected sibs and zero, one, or both parents typed. We report false-positive rates, overall rank by power, and the power for each statistic. We give rough recommendations regarding which programs provide the most powerful tests for linkage, as well as the programs to be avoided under certain conditions. For the likelihood-ratio-based statistics, we examined the effects of various treatments of sibships with multiple affected individuals. Finally, we explored the use of some simple two-of-three composite statistics and found that such tests are of only marginal benefit over the most powerful single statistic.
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