ArticleAmerican journal of human genetics1997
Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Screening of Human Proteins for Fluoride and Aluminum Binding.Bioinformation · 2018Article
- Family History in Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2016Article
- Biosynthesis of glycosaminoglycans: associated disorders and biochemical tests.Journal of inherited metabolic disease · 2016Review
- Genome-wide association study of recurrent early-onset major depressive disorder.Molecular psychiatry · 2011Article
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
- Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families.American journal of human genetics · 2004Article
- Trapping and sequence analysis of 1138 putative exons from human chromosome 18.Molecular psychiatry · 2003Article
- Chromosomal abnormalities and mental illness.Molecular psychiatry · 2003Review
- Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.Molecular psychiatry · 2003Article
- A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder.Molecular psychiatry · 2003Article
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
- A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes.Genome research · 2002Article
- Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.Molecular psychiatry · 2002Article
- The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report.Molecular psychiatry · 2002Article
- Manic-depression genes and the new millennium: poised for discovery.Molecular psychiatry · 2002Review
- Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.Molecular psychiatry · 2002Article
- A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3.Molecular psychiatry · 2002Article
- A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.Molecular psychiatry · 2001Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several groups have reported evidence suggesting linkage of bipolar affective disorder (BPAD) to chromosome 18. We have reported data from 28 pedigrees that showed linkage to marker loci on 18p and to loci 40 cM distant on 18q. Most of the linkage evidence derived from families with affected phenotypes in only the paternal lineage and from marker alleles transmitted on the paternal chromosome. We now report results from a series of 30 new pedigrees (259 individuals) genotyped for 13 polymorphic markers spanning chromosome 18. Subjects were interviewed by a psychiatrist and were diagnosed by highly reliable methods. Genotypes were generated with automated technology and were scored blind to phenotype. Affected sib pairs showed excess allele sharing at the 18q markers D18S541 and D18S38. A parent-of-origin effect was observed, but it was not consistently paternal. No robust evidence of linkage was detected for markers elsewhere on chromosome 18. Multipoint nonparametric linkage analysis in the new sample combined with the original sample of families supports linkage on chromosome 18q, but the susceptibility gene is not well localized.
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