ArticleNucleic acids research1998
Software and database for the analysis of mutations in the human WT1 gene.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- New mutation in WT1 gene in a boy with an incomplete form of Denys-Drash syndrome: A CARE-compliant case report.Medicine · 2021Article
- Genetics of pediatric renal tumors.Pediatric nephrology (Berlin, Germany) · 2013Review
- A novel WT1 heterozygous nonsense mutation (p.K248X) causing a mild and slightly progressive nephropathy in a 46,XY patient with Denys-Drash syndrome.Pediatric nephrology (Berlin, Germany) · 2011Article
- WT1 and glomerular diseases.Pediatric nephrology (Berlin, Germany) · 2006Review
- Genetic forms of nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Review
- Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour.Oncogene · 2002Article
- Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1.Genes & development · 2001Article
- Frasier and Denys-Drash syndromes: different disorders or part of a spectrum?Archives of disease in childhood · 1999Review
- WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis.The American journal of pathology · 1999Article
- Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database.American journal of human genetics · 1998Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WT1 gene, located at 11p13, encodes a zinc finger transcription factor involved in renal and gonadal development and in Wilms' tumor. Constitutional mutations of this gene have been described in most patients with Denys Drash syndrome (mesangial sclerosis associated with male pseudohermaphrodism and/or Wilms' tumor), but also in patients with genitourinary abnormalities and Wilms' tumor (WT) or presenting with only unilateral or bilateral WT. Moreover, approximately 10% of Wilms' tumors carry WT1 mutations at the somatic level. To facilitate the genotype-phenotype correlation analyses, we have created a software package along with a computerized database of germline (70 entries) and somatic (28 entries) mutations reported in the literature.
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