ArticleNucleic acids research1998
BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 150 citations in OpenAlex.
- BTKbase, Bruton Tyrosine Kinase Variant Database in X-Linked Agammaglobulinemia: Looking Back and Ahead.Human mutation · 2023Article
- Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?International journal of molecular sciences · 2019Review
- Review
- Targeting B cells in treatment of autoimmunity.Current opinion in immunology · 2016Review
- Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Frontiers in immunology · 2015Review
- X-linked immunodeficiencies.Current allergy and asthma reports · 2004Review
- XLA patients with BTK splice-site mutations produce low levels of wild-type BTK transcripts.Journal of clinical immunology · 2002Article
- Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia.Journal of clinical immunology · 2002Article
- The clinical spectrum of Bruton's agammaglobulinemia.Current allergy and asthma reports · 2001Review
- Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults.Respiratory research · 2001Article
- The transcription factor, Bright, and immunoglobulin heavy chain expression.Immunologic research · 2001Review
- Primary immunodeficiency diseases in Norway.Journal of clinical immunology · 2000Article
- X-linked agammaglobulinemia.Clinical reviews in allergy & immunology · 2000Review
- Detection of Bruton's tyrosine kinase mutations in hypogammaglobulinaemic males registered as common variable immunodeficiency (CVID) in the Japanese Immunodeficiency Registry.Clinical and experimental immunology · 2000Article
- Kinase mutant Btk results in atypical X-linked agammaglobulinaemia phenotype.Clinical and experimental immunology · 2000Article
- Early B cell defects.Clinical and experimental immunology · 2000Review
- KinMutBase, a database of human disease-causing protein kinase mutations.Nucleic acids research · 2000Article
- Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.The EMBO journal · 1998Article
- X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.Springer seminars in immunopathology · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton's agammaglobulinemia tyrosine kinase (BTK). A database (BTKbase) of BTK mutations has been compiled and the recent update lists 463 mutation entries from 406 unrelated families showing 303 unique molecular events. In addition to mutations, the database also lists variants or polymorphisms. Each patient is given a unique patient identity number (PIN). Information is included regarding the phenotype including symptoms. Mutations in all the five domains of BTK have been noticed to cause the disease, the most common event being missense mutations. The mutations appear almost uniformly throughout the molecule and frequently affect CpG sites that code for arginine residues. The putative structural implications of all the missense mutations are given in the database. The improved version of the registry having a number of new features is available at http://www. helsinki.fi/science/signal/btkbase.html
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.