ArticleDigestive diseases and sciences1997
Submandibular gland peptide-T (SGP-T) inhibits intestinal anaphylaxis.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein.Journal of inflammation (London, England) · 2010Article
- The tripeptide feG inhibits leukocyte adhesion.Journal of inflammation (London, England) · 2008Article
- Effect of electroacupuncture at Sibai on the gastric myoelectric activities of denervated rats.World journal of gastroenterology · 2006Article
- The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils.Journal of inflammation (London, England) · 2006Article
- The tripeptide FEG ameliorates systemic inflammatory responses to rat intestinal anaphylaxis.BMC physiology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel peptide, submandibular gland peptide-T (SGP-T), which reduces allergen-induced hypotension, was examined for effects on intestinal anaphylaxis. Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivo myoelectric activity of the jejunum. The disruption of migrating myoelectric complexes (MMCs) that occurs upon intraluminal, duodenal challenge with antigen of sensitized rats was inhibited by 75% upon intravenous treatment with 100 micrograms/kg of SGP-T. In addition, SGP-T reduced the number of rats experiencing anaphylactic diarrhea and disrupted MMCs, but the peptide did not alter antigen-provoked release of rat mast cell protease II. The mechanism of action of SGP-T remains to be determined, but it apparently does not act directly on mast cells to exert its antianaphylactic action. These results emphasize that modulation of immediate hypersensitivity reactions is only one of several gastrointestinal activities that are affected by growth factors and peptides released from salivary glands.
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Registered trials
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