ArticleDigestive diseases and sciences1997
Adrenergic denervation hypersensitivity in ileal circular smooth muscle after small bowel transplantation in rats.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
- Effect of chronic, extrinsic denervation on functional NANC innervation with vasoactive intestinal polypeptide and substance P in longitudinal muscle of rat jejunum.Neurogastroenterology and motility · 2008Article
- Long-term effects of extrinsic denervation on VIP and substance P innervation in circular muscle of rat jejunum.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Acute denervation alters the epithelial response to adrenoceptor activation through an increase in alpha1-adrenoceptor expression on villus enterocytes.British journal of pharmacology · 2006Article
- alpha- and beta-adrenergic receptor mechanisms in spontaneous contractile activity of rat ileal longitudinal smooth muscle.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2005Article
- Effect of ileo-jejunal transposition on ileal longitudinal smooth muscle contractility in vitro in rats.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2004Article
- Nitrergic mechanisms mediating inhibitory control of longitudinal smooth muscle contraction in mouse small intestine.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2004Article
- New method for evaluating intestinal contractions in guinea pig by curve fitting.Digestive diseases and sciences · 2000Article
- Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Contractile activity of circular smooth muscle in rats one year after small bowel transplantation: differing adaptive response of the jejunum and ileum to denervation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Nitric oxide pathways in circular muscle of the rat jejunum before and after small bowel transplantation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Small bowel transplantation induces adrenergic hypersensitivity in ileal longitudinal smooth muscle in rats.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Neuronal adrenergic and muscular cholinergic contractile hypersensitivity in canine jejunum after extrinsic denervation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Effects of small bowel transplantation (SBT) on ileal motility are unknown. The aim of the present study was to investigate changes in spontaneous contractile activity and sensitivity to cholinergic and adrenergic agents in the ileal circular muscle after SBT in rats. Orthotopic SBT was performed in syngeneic rats to avoid immune phenomena. Distal ileal circular muscle strips from rats one week (N = 10) and eight weeks (N = 10) after SBT were stretched to optimal length (Lo), and basal spontaneous activity at Lo was measured. Dose-response experiments to the cholinergic agonist bethanechol (Be, 10(-8)-10(-4) M) were performed in the presence of tetrodotoxin (TTX, 10(-6) M) and to the adrenergic agonist norepinephrine (NE, 10(-8)-10(-4) M) with or without TTX. ED50 (negative log of drug-concentration that induced 50% effect) was calculated. We also studied rats with selective jejunoileal ischemia/ reperfusion, intestinal transection/reanastomosis, naive controls, and sham operated controls (N > or = 8/group). Spontaneous basal activity did not differ among groups. Sensitivity to Be was not different in rats after SBT or in other groups compared to control tissue. After SBT, hypersensitivity to NE was shown by a significant increase of ED50 at one and eight weeks after SBT (5.1 +/- 0.3 vs 6.2 +/- 0.4 and 6.2 +/- 0.2, respectively; P < 0.05) regardless of the presence of TTX. No hypersensitivity was observed after ischemia-reperfusion intestinal transection-reanastomosis, or sham operation. It is concluded that ileal hypersensitivity to NE was related to the extrinsic denervation obligated by the transplantation procedure, possibly mediated through an increase in number of receptors on smooth muscle, not on the enteric nerves.
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