Evidence map›Paper›PMID 9397401›Full record

ArticleLipids1997

Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs.

G E Billman, J X Kang, A Leaf

Abstract read
PubMed Publisher
In one paragraph

Article in Lipids, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  6. Review
  7. Review
  8. Article
  9. Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs.Animals : an open access journal from MDPI · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
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  16. Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

G E BillmanDepartment of Physiology, Ohio State University, Columbus 45210, USA.
J X Kang
A Leaf
Massachusetts General Hospital · USThe Ohio State University · US

Funding

MECHANISMS OF DISEASE PREVENTION OF N-3 FATTY ACIDSR01DK038165 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEAF, ALEXANDER · 1988 to 1999
–
NIDDK NIH HHS DK38165
6 · The paper itself

Abstract

The objective of this study was to obtain functional information associated with the prevention by n-3 polyunsaturated fatty acids (PUFA) of ischemia-induced fatal cardiac ventricular arrhythmias in the intact, conscious, exercising dog. Thirteen dogs susceptible to ischemia-induced ventricular fibrillation were prepared surgically by ligation of their anterior descending left coronary artery and placement of an inflatable cuff around their left circumflex artery. After 4 wk of recovery, exercise-plus-ischemia tests were performed without and then with an intravenous infusion of an emulsion of free n-3 PUFA just prior to occluding the left circumflex artery while the animals were running on a treadmill. One week later the exercise-plus-ischemia test was repeated but with a control infusion replacing the emulsion of n-3 PUFA. The infusion of the free n-3 PUFA in quantities of 1.0 to 10 g prevented ventricular fibrillation in 10 of the 13 dogs tested (P < 0.005), apparently without esterification of the PUFA into membrane phospholipids. The antiarrhythmic effect of the n-3 PUFA was associated with slowing of the heart rate, shortening of the QT-interval (electrical action potential duration), reduction of left ventricular systolic pressure, and prolongation of the electrocardiographic atrial-ventricular conduction time (P-R interval). These effects are comparable with those we have reported in studies with cultured neonatal rat cardiac myocytes.

Indexed as

AnimalsConstrictionCoronary VesselsDeath, Sudden, CardiacDogsElectrocardiographyEmulsionsFatty Acids, Omega-3Fish OilsHeart Conduction SystemHeart RateMyocardial IschemiaPhysical ExertionPressureRatsVentricular FibrillationEmulsionsFatty Acids, Omega-3Fish Oils

Identifiers

PMID9397401
OpenAlexW1998430513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.