ArticleNucleic acids research1997
Differential effect of H1 variant overproduction on gene expression is due to differences in the central globular domain.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role of charges in a dynamic disordered complex between an IDP and a folded domain.Nature communications · 2025Article
- Reversible Histone Modifications Contribute to the Frozen and Thawed Recovery States of Wood Frog Brains.Biomolecules · 2024Article
- Histone variants: The unsung guardians of the genome.DNA repair · 2022Review
- Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.Protein science : a publication of the Protein Society · 2022Article
- Linker Histone in Diseases.International journal of biological sciences · 2017Review
- Nuclear and nucleolar activity of linker histone variant H1.0.Cellular & molecular biology letters · 2016Review
- Human linker histones: interplay between phosphorylation and O-β-GlcNAc to mediate chromatin structural modifications.Cell division · 2011Article
- Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0).The Journal of biological chemistry · 2010Article
- Histone H1 subtypes differentially modulate chromatin condensation without preventing ATP-dependent remodeling by SWI/SNF or NURF.PloS one · 2009Article
- An archaeal histone-like protein mediates efficient p53 gene transfer and facilitates its anti-cancer effect in vitro and in vivo.Cancer gene therapy · 2007Article
- Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.Nature structural & molecular biology · 2006Article
- Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins.The Journal of cell biology · 2005Article
- Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation.Molecular and cellular biology · 2002Article
- Histone variants: are they functionally heterogeneous?Genome biology · 2001Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vivo overproduction of two mouse histone H1 variants in homologous mouse fibroblasts has opposite effects on gene expression. Overproduction of H1(0) results in repression of transcript levels of all polymerase II genes tested. In contrast, overproduction of H1c results in elevated levels of transcripts. We created a series of chimeric H1 genes in which the regions encoding the three structural domains common to this family of these proteins were systematically switched. Overexpression of these genes in vivo resulted in the accumulation of large amounts of the chimeric H1 in chromatin. Analysis of the effects of overproduction of these proteins revealed that the differential effect of H1 variant overproduction on gene expression is due to differences in the central globular domain.
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