ArticleNucleic acids research1997
CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
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- The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.Nucleic acids research · 2012Article
- Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Cancer cell · 2011Article
- Function of the A-type cyclins during gametogenesis and early embryogenesis.Results and problems in cell differentiation · 2011Review
- A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer.Neoplasia (New York, N.Y.) · 2009Article
- Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression.Oncogene · 2008Article
- Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.Molecular and cellular biology · 2008Article
- Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest.The Biochemical journal · 2006Article
- Targeting proliferating tumor cells via the transcriptional control of therapeutic genes.Cancer gene therapy · 2006Article
- Inhibition of cell proliferation and induction of apoptosis by novel tetravalent peptides inhibiting DNA binding of E2F.Oncogene · 2003Article
- Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development.The Plant cell · 2002Article
- A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites.Nucleic acids research · 2002Article
- Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.Molecular and cellular biology · 2001Article
- Transactivation of murine cyclin A by polyomavirus large and small T antigens.Journal of virology · 2001Article
- Control of cell cycle progression in human mesothelioma cells treated with gamma interferon.Oncogene · 2001Article
- Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements.The Plant cell · 2000Article
- Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells.Molecular and cellular biology · 2000Article
- Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells.Molecular and cellular biology · 2000Article
- Distinct cellular factors regulate the c-myb promoter through its E2F element.Molecular and cellular biology · 1999Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cdc25C , cdc2 and cyclin A promoters are controlled by transcriptional repression through two contiguous protein binding sites, termed the CDE and CHR. In the present study we have identified a factor, CDF-1, which interacts with the cdc25C CDE-CHR module. CDF-1 binds to the CDE in the major groove and to the CHR in the minor grove in a cooperative fashion in vitro , in a manner similar to that seen by genomic footprinting. In agreement with in vivo binding data and its putative function as a periodic repressor, DNA binding by CDF-1 in nuclear extracts is down-regulated during cell cycle progression. CDF-1 also binds avidly to the CDE-CHR modules of the cdc2 and cyclin A promoters, but not to the E2F site in the B- myb promoter. Conversely, E2F complexes do not recognize the cdc25C CDE-CHR and CDF-1 is immunologically unrelated to all known E2F and DP family members. This indicates that E2F- and CDF-mediated repression is controlled by different factors acting at different stages during the cell cycle. While E2F-mediated repression seems to be associated with genes that are up-regulated early (around mid G1), such as B- myb , CDE-CHR-controlled genes, such as cdc25C , cdc2 and cyclin A , become derepressed later. Finally, the fractionation of native nuclear extracts on glycerol gradients leads to separation of CDF-1 from both E2F complexes and pocket proteins of the pRb family. This emphasizes the conclusion that CDF-1 is not an E2F family member and points to profound differences in the cell cycle regulation of CDF-1 and E2F.
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