ReviewNucleic acids research1997
A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators.
Review in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Biochemical and epigenomic dissection of TFIIE function reveals gene-selective requirement in human transcription.Scientific reports · 2026Article
- Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.Molecular biology of the cell · 2005Article
- Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors.Molecular and cellular biology · 2003Article
- The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genes.Eukaryotic cell · 2002Article
- A target essential for the activity of a nonacidic yeast transcriptional activator.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s.Molecular and cellular biology · 2002Article
- Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol II.Molecular and cellular biology · 2002Article
- Degeneracy and complexity in biological systems.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.Journal of virology · 2001Article
- AMF1 (GPS2) modulates p53 transactivation.Molecular and cellular biology · 2001Article
- High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.Molecular and cellular biology · 2001Article
- An initiation element in the yeast CUP1 promoter is recognized by RNA polymerase II in the absence of TATA box-binding protein if the DNA is negatively supercoiled.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.Molecular and cellular biochemistry · 2000Article
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth.Molecular and cellular biology · 2000Article
- MCM proteins are associated with RNA polymerase II holoenzyme.Molecular and cellular biology · 1999Article
- Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure.Molecular and cellular biology · 1999Article
- The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA.Molecular and cellular biology · 1999Article
- Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The already complex process of transcription by RNA polymerase II has become even more complicated in the last few years with the identification of auxiliary factors in addition to the essential general initiation factors. In many cases these factors, which have been termed mediators or co-activators, are only required for activated or repressed transcription. In some cases the effects are specific for certain activators and repressors. Recently some of these auxiliary factors have been found in large complexes with either TBP, as TBP-associated factors (TAFs) in the general factor TFIID, or with pol II and a subset of the general factors, referred to as the 'holoenzyme'. Although the exact composition of these huge assemblies is still a matter of some debate, it is becoming clear that the complexes themselves come in more than one form. In particular, at least four forms of TFIID have been described, including one that contains a tissue-specific TAF and another with a cell type-specific form of TBP. In addition, in yeast there are at least two forms of the 'holoenzyme' distinguished by their mediator composition and by the spectrum of transcripts whose expression they affect. Genetic and biochemical analyses have begun to identify the interactions between the components of these complexes and the ever increasing family of DNA binding regulatory factors. These studies are complicated by the fact that individual regulatory factors often appear to have redundant interactions with multiple mediators. The existence of these different forms of transcription complexes defines a new target for regulation of subsets of eukaryotic genes.
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