ArticleThe Journal of experimental medicine1997
Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- Mechanisms of B Cell Tolerance in Health and Autoimmunity.Arthritis & rheumatology (Hoboken, N.J.) · 2026Review
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.Nature communications · 2021Article
- B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.The Journal of experimental medicine · 2020Article
- Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis.Frontiers in immunology · 2020Article
- The Complex Association of FcγRIIb With Autoimmune Susceptibility.Frontiers in immunology · 2019Review
- Thyroid Autoantibodies Display both "Original Antigenic Sin" and Epitope Spreading.Frontiers in immunology · 2017Review
- Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.Endocrine reviews · 2014Review
- Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The Journal of experimental medicine · 2011Article
- Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.The Journal of experimental medicine · 2004Article
- Maintenance and loss of self-tolerance in B cells.Springer seminars in immunopathology · 2001Review
- Virus-induced maturation and activation of autoreactive memory B cells.The Journal of experimental medicine · 2000Article
- T cell-independent rescue of B lymphocytes from peripheral immune tolerance.Science (New York, N.Y.) · 2000Article
- B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice.The Journal of experimental medicine · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. In contrast to the deletion of autoreactive B cells triggered by systemic mHEL (Hartley, S.B., J. Crosbie, R. Brink, A.B. Kantor, A. Basten, and C.C. Goodnow. 1991. Nature. 353:765-769), selective expression of mHEL autoantigen on thyroid cells did not trigger elimination or inactivation of circulating HEL-reactive B cells. These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.