ArticleThe Journal of experimental medicine1997
Association with FcRgamma is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 161 citations in OpenAlex.
- Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia.iScience · 2026Article
- ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- GM-CSF-mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity toScience immunology · 2025Article
- Classification of NK-large granular lymphocytic leukemia by CD56 expression.The oncologist · 2025Article
- ITAM-based receptors in natural killer cells.Immunological reviews · 2024Review
- The diverse roles of C-type lectin-like receptors in immunity.Frontiers in immunology · 2023Review
- Largely preserved functionality after the combined loss of NKG2D, NCR1 and CD16 demonstrates the remarkable plasticity of NK cell responsiveness.Frontiers in immunology · 2023Article
- In the absence of natural killer cell activation donor-specific antibody mediates chronic, but not acute, kidney allograft rejection.Kidney international · 2019Article
- Inside-Out Control of Fc-Receptors.Frontiers in immunology · 2019Review
- Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells.Journal of experimental & clinical cancer research : CR · 2018Article
- Role of NKp46EMBO molecular medicine · 2018Article
- Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.EBioMedicine · 2017Article
- Chronic NKG2D EngagementFrontiers in immunology · 2017Article
- The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.Frontiers in immunology · 2017Review
- Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- CD160 is essential for NK-mediated IFN-γ production.The Journal of experimental medicine · 2015Article
- Role of the complement system in NK cell-mediated antitumor T-cell responses.Oncoimmunology · 2014Article
- Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.Frontiers in immunology · 2014Review
- Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.Blood · 2013Article
- Role of complement and NK cells in antibody mediated rejection.Human immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells exhibit cytotoxicity against variety of tumor cells and virus-infected cells without prior sensitization and represent unique lymphocytes involved in primary host defense. NKR-P1 is thought to be one of NK receptors mediating activation signals because cross-linking of NKR-P1 activates NK cells to exhibit cytotoxicity and IFN-gamma production. However, molecular mechanism of NK cell activation via NKR-P1 is not well elucidated. In this study, we analyzed the cell surface complex associated with NKR-P1 on NK cells and found that NKR-P1 associates with the FcRgamma chain which is an essential component of Fc receptors for IgG and IgE. The association between FcRgamma and NKR-P1 is independent of Fc receptor complexes. Furthermore, NK cells from FcRgamma-deficient mice did not show cytotoxicity or IFN-gamma production upon NKR-P1 cross-linking. Similarly, NK1.1+ T cells from FcRgamma-deficient mice did not produce IFN-gamma upon NKR-P1 crosslinking. These findings demonstrate that the FcRgamma chain plays an important role in activation of NK cells via the NKR-P1 molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.