ArticleThe Journal of cell biology1997
Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 62 citations in OpenAlex.
- Igβ ubiquitination activates PI3K signals required for endosomal sorting.The Journal of experimental medicine · 2017Article
- A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.PloS one · 2014Article
- Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy.Molecular immunology · 2011Review
- Fused late endocytic compartments and immunostimulatory capacity of dendritic-tumor cell hybridomas.The Journal of membrane biology · 2009Article
- Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes.Molecular biology of the cell · 2008Article
- A translocated bacterial protein protects vascular endothelial cells from apoptosis.PLoS pathogens · 2006Article
- Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.Molecular biology of the cell · 2005Article
- Multifaceted role of the ubiquitin ligase Itch in immune regulation.Immunology and cell biologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii). After removal of the invariant chain, peptides can be loaded onto class II molecules, a process catalyzed by human leukocyte antigen-DM (HLA-DM) molecules. Here we show that MHC class II compartments consist of two physically and functionally distinct organelles. Newly synthesized MHC class II/Ii complexes were targeted to endocytic organelles lacking HLA-DM molecules, where Ii degradation occurred. From these organelles, class II molecules were transported to a distinct organelle containing HLA-DM, in which peptides were loaded onto class II molecules. This latter organelle was not directly accessible via fluid phase endocytosis, suggesting that it is not part of the endosomal pathway. Uptake via antigen-specific membrane immunoglobulin resulted however in small amounts of antigen in the HLA-DM positive organelles. From this peptide-loading compartment, class II-peptide complexes were transported to the plasma membrane, in part after transit through endocytic organelles. The existence of two separate compartments, one involved in Ii removal and the other functioning in HLA-DM-dependent peptide loading of class II molecules, may contribute to the efficiency of antigen presentation by the selective recruitment of peptide-receptive MHC class II molecules and HLA-DM to the same subcellular location.
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