ReviewMolecular neurobiology1997
Alcohol, astroglia, and brain development.
Review in Molecular neurobiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 155 citations in OpenAlex.
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
- ERK1/2 Signalling Pathway Regulates Tubulin-Binding Cofactor B Expression and Affects Astrocyte Process Formation after Acute Foetal Alcohol Exposure.Brain sciences · 2022Article
- Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure.Frontiers in cellular neuroscience · 2022Article
- Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer's Disease.Biomedicines · 2021Article
- Altering Cell-Cell Interaction in Prenatal Alcohol Exposure Models: Insight on Cell-Adhesion Molecules During Brain Development.Frontiers in molecular neuroscience · 2021Review
- Astroglia in the Vulnerability and Maintenance of Alcohol Use Disorders.Advances in neurobiology · 2021Article
- Neuroglia in Psychiatric Disorders.Advances in neurobiology · 2021Article
- Molecular Neuropathology of Astrocytes and Oligodendrocytes in Alcohol Use Disorders.Frontiers in molecular neuroscience · 2018Review
- Inattention and impulsivity associated with prenatal alcohol exposure in a prospective cohort study with 11-years-old Brazilian children.European child & adolescent psychiatry · 2016Observational
- Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain.Acta neuropathologica communications · 2013Article
- Involvement of sphingolipids in ethanol neurotoxicity in the developing brain.Brain sciences · 2013Article
- Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway.Brain and behavior · 2013Article
- Enforced Pax6 expression rescues alcohol-induced defects of neuronal differentiation in cultures of human cortical progenitor cells.Alcoholism, clinical and experimental research · 2012Article
- An in vitro model for studying the effects of continuous ethanol exposure on N-methyl-D-aspartate receptor function.Alcohol (Fayetteville, N.Y.) · 2012Article
- Glial and glutamatergic markers in depression, alcoholism, and their comorbidity.Journal of affective disorders · 2010Article
- Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study.Neuroreport · 2010Article
- Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis.Virology journal · 2009Article
- Neuroimaging and fetal alcohol spectrum disorders.Developmental disabilities research reviews · 2009Review
- Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults.Brain imaging and behavior · 2008Article
- Ethanol teratogenesis in Japanese medaka: effects at the cellular level.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glial cells constitute one of the most common cell types in the brain. They play critical roles in central nervous system (CNS) development. Recent evidence demonstrates that glial cells are profoundly affected by prenatal alcohol exposure, suggesting that alterations in these cells may participate in CNS abnormalities associated with ethanol-induced teratogenesis. In vivo studies show that prenatal exposure to alcohol hampers myelinogenesis and is associated with neuroglial heterotopias and abnormal astrogliogenesis. Studies using primary cultures of rat cortical astrocytes show that ethanol affects DNA, RNA, and protein synthesis, decreases the number of mitotic cells, alters the content and distribution of several cytoskeletal proteins including the astroglial marker, glial fibrillary acidic protein (GFAP), and the levels of plasma-membrane glycoproteins, reduces the capacity of astrocytes to secrete growth factors, and induces oxidative stress. Furthermore, ethanol exposure during early embryogenesis alters the normal development of radial glia cells (the main astrocytic precursors), delays the onset of GFAP expression, and decreases mRNA GFAP levels in fetal and postnatal brains and in radial glia and astrocytes in primary culture. Recent evidence suggests that ethanol interferes with the transcription process of GFAP, thus leading to a reduction in GFAP-gene expression during astrogliogenesis. However, brief exposure of rats to high levels of ethanol during the neonatal period (the period of astrocyte differentiation) causes a transient gliosis, with an increase in GFAP and its mRNA levels. These findings indicate that astroglial cells are an important target of ethanol toxicity during central nervous system (CNS) development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.