ArticleInfection and immunity1997
Pathogenicity and protective effect of rough mutants of Salmonella species in germ-free piglets.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
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- Systems Biology and Pangenome ofmBio · 2019Article
- Engineering of a rough auxotrophic mutantOncotarget · 2018Article
- Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity.PLoS pathogens · 2016Article
- Innate immune response in the gut against Salmonella - review.Folia microbiologica · 2010Review
- Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils.Infection and immunity · 2007Article
- Article
- Rapid protection of gnotobiotic pigs against experimental salmonellosis following induction of polymorphonuclear leukocytes by avirulent Salmonella enterica.Infection and immunity · 2003Article
- Systemic and local cytokine response of young piglets to oral infection with Salmonella enterica serotype Typhimurium.Folia microbiologica · 2003Article
- Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.Folia microbiologica · 2001Article
- Cytokines in Salmonella infection.Folia microbiologica · 1999Article
- Salmonellosis: lessons drawn from a germ-free pig model.Folia microbiologica · 1998Article
- Cellular changes and cytokine expression in the ilea of gnotobiotic piglets resulting from peroral Salmonella typhimurium challenge.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, two stable, rough, streptomycin-sensitive Salmonella mutants with different types of genetic defects were used to colonize groups of germ-free (GF) piglets. The lipopolysaccharide (LPS) of Salmonella typhimurium SF 1591 was of the Ra chemotype (complete core), whereas the LPS of the S. minnesota mR 595 deep-rough mutant contained only lipid A and 2-keto-3-deoxyoctulosonic acid (Re chemotype). Both strains readily colonized the intestinal tracts of GF piglets and were stable during the whole experiment. All animals survived, and only transient fever was observed in some piglets colonized with the SF 1591 strain. Finally, streptomycin and virulent, smooth, streptomycin-resistant S. typhimurium LT2 were administered perorally 1 week later. All piglets colonized previously with the deep-rough mutant mR 595 died of sepsis, in contrast to piglets infected with the LT2 strain and colonized with the SF 1591 mutant, all of which survived. This difference is explained by the penetration of the mesenteric lymph nodes, spleen, and liver by great numbers of live bacteria in the latter case, resulting in prominent systemic and local immune responses. On the other hand, live bacteria were found only rarely in the mesenteric lymph nodes of animals colonized with the mR 595 strain and a negligible antibody response was observed.
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