ArticleJournal of bacteriology1997
The arginine deiminase pathway in Rhizobium etli: DNA sequence analysis and functional study of the arcABC genes.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Exploring the Metabolic Response of Pseudomonas putida to L-arginine.Advances in experimental medicine and biology · 2025Article
- What determines symbiotic nitrogen fixation efficiency in rhizobium: recent insights into Rhizobium leguminosarum.Archives of microbiology · 2023Review
- Arginine Deiminase and Biotin Metabolism Signaling Pathways Play an Important Role in Human-Derived Serotype V, ST1 Streptococcus agalactiae Virulent Strain upon Infected Tilapia.Animals : an open access journal from MDPI · 2020Article
- Transposition of ISApplied and environmental microbiology · 2019Article
- Crosstalk between sugarcane and a plant-growth promoting Burkholderia species.Scientific reports · 2016Article
- Article
- Canonical and non-canonical EcfG sigma factors control the general stress response in Rhizobium etli.MicrobiologyOpen · 2013Article
- Investigation into the physiologies of Aeromonas veronii in vitro and inside the digestive tract of the medicinal leech using RNA-seq.The Biological bulletin · 2012Article
- Genome-wide detection of predicted non-coding RNAs in Rhizobium etli expressed during free-living and host-associated growth using a high-resolution tiling array.BMC genomics · 2010Article
- Metabolic reconstruction and modeling of nitrogen fixation in Rhizobium etli.PLoS computational biology · 2007Article
- The Bradyrhizobium japonicum Fur protein is an iron-responsive regulator in vivo.Molecular genetics and genomics : MGG · 2006Article
- Structure, regulation, and putative function of the arginine deiminase system of Streptococcus suis.Journal of bacteriology · 2006Article
- Regulatory role of Rhizobium etli CNPAF512 fnrN during symbiosis.Applied and environmental microbiology · 2004Article
- Arginine catabolism by sourdough lactic acid bacteria: purification and characterization of the arginine deiminase pathway enzymes from Lactobacillus sanfranciscensis CB1.Applied and environmental microbiology · 2002Article
- Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1.Applied and environmental microbiology · 2002Article
- Gene structure, organization, expression, and potential regulatory mechanisms of arginine catabolism in Enterococcus faecalis.Journal of bacteriology · 2002Article
- Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein.Infection and immunity · 2000Article
- High-resolution physical map of the Sinorhizobium meliloti 1021 pSyma megaplasmid.Journal of bacteriology · 2000Article
- The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by the arginine repressor argR.Journal of bacteriology · 1998Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence analysis upstream of the Rhizobium etli fixLJ homologous genes revealed the presence of three open reading frames homologous to the arcABC genes of Pseudomonas aeruginosa. The P. aeruginosa arcABC genes code for the enzymes of the arginine deiminase pathway: arginine deiminase, catabolic ornithine carbamoyltransferase (cOTCase), and carbamate kinase. OTCase activities were measured in free-living R. etli cells and in bacteroids isolated from bean nodules. OTCase activity in free-living cells was observed at a different pH optimum than OTCase activity in bacteroids, suggesting the presence of two enzymes with different characteristics and different expression patterns of the corresponding genes. The characteristics of the OTCase isolated from the bacteroids were studied in further detail and were shown to be similar to the properties of the cOTCase of P. aeruginosa. The enzyme has a pH optimum of 6.8 and a molecular mass of approximately 450 kDa, is characterized by a sigmoidal carbamoyl phosphate saturation curve, and exhibits a cooperativity for carbamoyl phosphate. R. etli arcA mutants, with polar effects on arcB and arcC, were constructed by insertion mutagenesis. Bean nodules induced by arcA mutants were still able to fix nitrogen but showed a significantly lower acetylene reduction activity than nodules induced by the wild type. No significant differences in nodule dry weight, plant dry weight, and number of nodules were found between the wild type and the mutants. Determination of the OTCase activity in extracts from bacteroids revealed a strong decrease in activity of this enzyme in the arcA mutant compared to the wild-type strain. Finally, we observed that expression of an R. etli arcA-gusA fusion was strongly induced under anaerobic conditions.
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