ArticleProceedings of the National Academy of Sciences of the United States of America1997
Altered gene expression in the host brain caused by a trematode parasite: neuropeptide genes are preferentially affected during parasitosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 65 citations in OpenAlex.
- Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis.The Journal of comparative neurology · 2025Article
- The FMRF-NH2 gated sodium channel of Biomphalaria glabrata: Localization and expression following infection by Schistosoma mansoni.PLoS neglected tropical diseases · 2023Article
- FMRF-NHThe Journal of comparative neurology · 2021Article
- Identification and localization of a gonadotropin-releasing hormone-related neuropeptide in Biomphalaria, an intermediate host for schistosomiasis.The Journal of comparative neurology · 2021Article
- Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates.Frontiers in endocrinology · 2019Review
- Article
- RFamidergic neurons in the olfactory centers of the terrestrial slugZoological letters · 2018Article
- Central nervous system transcriptome of Biomphalaria alexandrina, an intermediate host for schistosomiasis.BMC research notes · 2017Article
- Transcriptomics of an extended phenotype: parasite manipulation of wasp social behaviour shifts expression of caste-related genes.Proceedings. Biological sciences · 2017Article
- Diversity of the RFamide Peptide Family in Mollusks.Frontiers in endocrinology · 2014Review
- Article
- Schistosomin from the snail Biomphalaria glabrata: expression studies suggest no involvement in trematode-mediated castration.Molecular and biochemical parasitology · 2009Article
- Endocrine disruption in aquatic pulmonate molluscs: few evidences, many challenges.Ecotoxicology (London, England) · 2007Review
- Behavioural manipulation in a grasshopper harbouring hairworm: a proteomics approach.Proceedings. Biological sciences · 2005Article
- Pharmacological and autoradiographical characterization of serotonin transporter-like activity in sporocysts of the human blood fluke, Schistosoma mansoni.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2003Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Schistosome parasites adjust the physiology and behavior of their intermediate molluscan hosts to their own benefit. Previous studies demonstrated effects of the avian-schistosome Trichobilharzia ocellata on peptidergic centers in the brain of the intermediate snail host Lymnaea stagnalis. In particular, electrophysiological properties and peptide release of growth- and reproduction-controlling neuroendocrine neurons were affected. We now have examined the possibility that the expression of genes that control physiology and behavior of the host might be altered during parasitosis. A cDNA library of the brain of parasitized Lymnaea was constructed and differentially screened by using mRNA from the brain of both parasitized and nonparasitized snails. This screening yielded a number of clones, including previously identified cDNAs as well as novel neuronal transcripts, which appear to be differentially regulated. The majority of these transcripts encode neuropeptides. Reverse Northern blot analysis confirmed that neuropeptide gene expression is indeed affected in parasitized animals. Moreover, the expression profiles of 10 transcripts tested showed a differential, parasitic stage-specific regulation. Changes in expression could in many cases already be observed between 1.5 and 5 hr postinfection, suggesting that changes in gene expression are a direct effect of parasitosis. We suggest that direct regulation of neuropeptide gene expression is a strategy of parasites to induce physiological and behavioral changes in the host.
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