ArticleProceedings of the National Academy of Sciences of the United States of America1997
Conservation of fibroblast growth factor function in lens regeneration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth.International journal of molecular sciences · 2025Article
- Macrophages modulate fibrosis during newt lens regeneration.Stem cell research & therapy · 2024Article
- Macrophages modulate fibrosis during newt lens regeneration.Research square · 2023Article
- In Vivo Imaging of Newt Lens Regeneration: Novel Insights Into the Regeneration Process.Translational vision science & technology · 2021Article
- Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.Current topics in developmental biology · 2021Review
- Lens regeneration in humans: using regenerative potential for tissue repairing.Annals of translational medicine · 2020Review
- Insights into regeneration tool box: An animal model approach.Developmental biology · 2019Review
- Diverse Evolutionary Origins and Mechanisms of Lens Regeneration.Molecular biology and evolution · 2018Review
- Lens regeneration: a historical perspective.The International journal of developmental biology · 2018Review
- A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration.Developmental biology · 2013Article
- Cell signaling pathways in vertebrate lens regeneration.Current topics in microbiology and immunology · 2013Review
- Lens regeneration in axolotl: new evidence of developmental plasticity.BMC biology · 2012Article
- Article
- Molecular and cellular aspects of amphibian lens regeneration.Progress in retinal and eye research · 2010Article
- Molecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review.Gerontology · 2010Review
- Gene expression profiles of lens regeneration and development in Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Retinal regeneration in the Xenopus laevis tadpole: a new model system.Molecular vision · 2009Article
- An essential role for FGF receptor signaling in lens development.Seminars in cell & developmental biology · 2006Review
- Signaling during lens regeneration.Seminars in cell & developmental biology · 2006Review
- The role of Pax-6 in lens regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In urodele amphibians, lens induction during development and regeneration occurs through different pathways. During development, the lens is induced from the mutual interaction of the ectoderm and the optic vesicle, whereas after lentectomy the lens is regenerated through the transdifferentiation of the iris-pigmented epithelial cells. Given the known role of fibroblast growth factors (FGFs) during lens development, we examined whether or not the expression and the effects of exogenous FGF during urodele lens regeneration were conserved. In this paper, we describe expression of FGF-1 and its receptors, FGFR-2 (KGFR and bek variants) and FGFR-3, in newts during lens regeneration. Expression of these genes was readily observed in the dedifferentiating pigmented epithelial cells, and the levels of expression were high in the lens epithelium and the differentiating fibers and lower in the retina. These patterns of expression implied involvement of FGFs in lens regeneration. To further elucidate this function, we examined the effects of exogenous FGF-1 and FGF-4 during lens regeneration. FGF-1 or FGF-4 treatment in lentectomized eyes resulted in the induction of abnormalities reminiscent to the ones induced during lens development in transgenic mice. Effects included transformation of epithelial cells to fiber cells, double lens regeneration, and lenses with abnormal polarity. These results establish that FGF molecules are key factors in fiber differentiation, polarity, and morphogenesis of the lens during regeneration even though the regenerating lens is induced by a different mechanism than in lens development. In this sense, FGF function in lens regeneration and development should be regarded as conserved. Such conservation should help elucidate the mechanisms of lens regeneration in urodeles and its absence in higher vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.